B-flow/spatiotemporal image correlation M-mode: novel ultrasound method that detects decrease in spiral artery luminal diameter in first trimester in primate model of impaired spiral artery remodeling.
B-flow/spatiotemporal image correlation M-mode: novel ultrasound method that detects decrease in spiral artery luminal diameter in first trimester in primate model of impaired spiral artery remodeling.
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B-Flow/时空图像相关M型：在灵长类螺旋动脉重构受损的动物模型中，检测妊娠早期螺旋动脉内径缩小的新超声方法。
DOI：
10.1002/uog.23753
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发表时间：
2022-03
影响因子：
7.1
通讯作者：
Albrecht, E. D.
中科院分区：
文献类型：
--
作者：
Turan, O. M.;Babischkin, J. S.;Aberdeen, G. W.;Turan, S.;Harman, C. R.;Pepe, G. J.;Albrecht, E. D.
旨在确定B流/时空图像相关（STIC）M型超声检查是否检测到螺旋动脉重塑（SAR）受损的非人灵长类动物模型在妊娠早期螺旋动脉管腔直径和容积流量减少。妊娠狒狒在妊娠前三个月（足月，184天）的第25-59天每天接受苯甲酸雌二醇治疗，或保持不治疗。在妊娠第60天，通过B-flow/STIC M-模式超声检查定量螺旋动脉管腔直径（7只未给药狒狒和12只雌二醇给药狒狒）和血流量（4只未给药狒狒和8只雌二醇给药狒狒）。此外，在15只未经处理的狒狒和18只雌二醇处理的狒狒中，通过免疫组织化学图像分析，对第60天通过剖腹产收集的胎盘基板组织进行离体定量绒毛外滋养层重塑的螺旋动脉百分比。比较了给药和未给药动物之间的结果。在接受B-flow/STIC M-模式超声和SAR定量的3只未处理狒狒和6只雌二醇处理狒狒中评估螺旋动脉管腔直径与SAR百分比之间的相关性。在雌二醇处理的狒狒中，绒毛外滋养层重塑的直径大于50 µm的螺旋动脉比例比未处理的动物低70%（P = 0.000001）。与未处理动物相比，SAR抑制狒狒在妊娠早期通过B-flow/STIC M-模式定量的收缩期和舒张期螺旋动脉管腔直径分别低31%（P = 0.014）和50%（P = 0.005），容积流量低85%（P = 0.014）。通过B-Flow/STIC M-模式超声检查量化的螺旋动脉腔直径与SAR百分比之间存在显着相关性（P < 0.05）。B-flow/STIC M-模式超声检查提供了一种新的真实的-时间无创方法，用于检测心脏周期内子宫螺旋动脉管腔直径和容积流量的减少，反映了SAR缺陷的非人灵长类动物模型在妊娠早期血管壁扩张性的降低。© 2021作者由John Wiley & Sons Ltd代表国际妇产科超声学会出版的《妇产科超声》。
To determine if B‐flow/spatiotemporal image correlation (STIC) M‐mode ultrasonography detects a decrease in spiral artery luminal diameter and volume flow during the first trimester in a non‐human primate model of impaired spiral artery remodeling (SAR). Pregnant baboons were treated daily with estradiol benzoate on days 25–59 of the first trimester (term, 184 days), or remained untreated. On day 60 of gestation, spiral artery luminal diameter (in seven untreated and 12 estradiol‐treated baboons) and volume flow (in four untreated and eight estradiol‐treated baboons) were quantified by B‐flow/STIC M‐mode ultrasonography. In addition, in 15 untreated and 18 estradiol‐treated baboons, the percent of spiral arteries remodeled by extravillous trophoblasts was quantified ex vivo by immunohistochemical image analysis on placental basal plate tissue collected via Cesarean section on day 60. Findings were compared between treated and untreated animals. The correlation between spiral artery luminal diameter and percent of SAR was assessed in three untreated and six estradiol‐treated baboons which underwent both B‐flow/STIC M‐mode ultrasound and quantification of SAR. The proportion of spiral arteries greater than 50 µm in diameter remodeled by extravillous trophoblasts was 70% lower in estradiol‐treated baboons than in untreated animals (P = 0.000001). Spiral artery luminal diameter in systole and diastole, as quantified by B‐flow/STIC M‐mode in the first trimester of pregnancy, was 31% (P = 0.014) and 50% (P = 0.005) lower, respectively, and volume flow was 85% lower (P = 0.014), in SAR‐suppressed baboons compared with untreated animals. There was a significant correlation between spiral artery luminal diameter as quantified by B‐flow/STIC M‐mode ultrasonography and the percent of SAR (P < 0.05). B‐flow/STIC M‐mode ultrasonography provides a novel real‐time non‐invasive method to detect a decrease in uterine spiral artery luminal diameter and volume flow during the cardiac cycle, reflecting decreased distensibility of the vessel wall, in the first trimester in a non‐human primate model of defective SAR. © 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
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影响因子：
9.8
作者：
Ilekis JV;Tsilou E;Fisher S;Abrahams VM;Soares MJ;Cross JC;Zamudio S;Illsley NP;Myatt L;Colvis C;Costantine MM;Haas DM;Sadovsky Y;Weiner C;Rytting E;Bidwell G
通讯作者：
Bidwell G
DOI：
10.1152/ajpheart.00590.2011
发表时间：
2012-05-01
影响因子：
4.8
作者：
Aberdeen, Graham W.;Bonagura, Thomas W.;Albrecht, Eugene D.
通讯作者：
Albrecht, Eugene D.
影响因子：
2
作者：
Llurba, Elisa;Turan, Ozhan;Baschat, Ahmet A.
通讯作者：
Baschat, Ahmet A.
DOI：
10.3109/14767058.2014.943177
发表时间：
2015-01-01
影响因子：
1.8
作者：
Hashish, Nawara;Hassan, Ayman;Youssef, M. A. F. M.
通讯作者：
Youssef, M. A. F. M.
影响因子：
1.9
作者：
HOUSTON, ML;HENDRICKX, AG
通讯作者：
HENDRICKX, AG