Efficacy and cost analysis of treating very low birth weight infants with erythropoietin during their first two weeks of life: a randomized, placebo-controlled trial.
Efficacy and cost analysis of treating very low birth weight infants with erythropoietin during their first two weeks of life: a randomized, placebo-controlled trial.
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在生命的前两周内使用促红细胞生成素治疗极低出生体重婴儿的功效和成本分析：一项随机、安慰剂对照试验。
DOI：
10.1016/s0022-3476(95)70462-0
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Christensen,RD
中科院分区：
文献类型：
--
作者：
Ohls,RK;Osborne,KA;Christensen,RD
目的我们假设使用较高剂量的促红细胞生成素 (Epo) 并在出生第一天开始治疗将减少呼吸机依赖和非呼吸机依赖的极低出生体重 (VLBW) 婴儿的输血需求。此外，我们假设这种治疗具有成本效益。方法我们随机分配 20 名患病的 VLBW 新生儿在出生后的前 2 周接受 Epo（每天 200 单位/公斤）或安慰剂。护理人员不知道治疗分配，并根据血细胞比容和贫血体征进行红细胞输注。结果第1天，两组的网织红细胞计数和血细胞比容相似。在接下来的两周内，安慰剂接受者的网织红细胞计数显着低于 Epo 接受者，但两组的血细胞比容没有差异。安慰剂接受者接受的输血次数（平均每名患者 1.4 次）多于 Epo 接受者（平均每名患者 0.2 次；p <0.01）。没有发现 Epo 的副作用，并且安慰剂组的费用超过了 Epo 组。结论我们得出的结论是，在生命的前 2 周内给 VLBW 婴儿施用 Epo 可以减少输血，并且具有成本效益。 （儿科杂志 1995；126：421-6）
ObjectiveWe hypothesized that using a higher dose of erythropoietin (Epo) and starting treatment on the first day of life would reduce the transfusion requirements of ventilator-dependent and non-ventilator-dependent very low birth weight (VLBW) infants. Moreover, we hypothesized that this treatment would be cost-effective.MethodsWe randomly assigned 20 ill newborn VLBW infants to receive either Epo (200 units/kg per day) or placebo during their first 2 weeks of life. The care-givers were unaware of the treatment assignments, and erythrocyte transfusions were administered according to hematocrit and signs of anemia.ResultsOn day 1, reticulocyte counts and hematocrits were similar in the two groups. During the subsequent 2 weeks, reticulocyte counts of the placebo recipients fell significantly below those of the Epo recipients, but hematocrits in the two groups did not differ. More transfusions were received by the placebo recipients (mean = 1.4 per patient) than by the Epo recipients (mean = 0.2 per patient; p <0.01). No adverse effects of Epo were noted, and the costs in the placebo group exceeded those in the Epo group.ConclusionsWe conclude that administration of Epo to VLBW infants during the first 2 weeks of life results in fewer transfusions and is cost-effective. (J Pediatr 1995;126:421-6)
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影响因子：
5.1
作者：
CARNIELLI, V;MONTINI, G;CANTARUTTI, F
通讯作者：
CANTARUTTI, F
重组促红细胞生成素治疗支气管肺发育不良贫血的随机、双盲、安慰剂对照试验。
DOI：
10.1016/s0022-3476(05)80401-9
发表时间：
1993
期刊：
The Journal of pediatrics
影响因子：
--
作者：
R. Ohls;D. Hunter;R. Christensen
通讯作者：
R. Christensen
对新生大鼠施用促红细胞生成素会导致中性粒细胞产生减少。
影响因子：
20.3
作者：
Christensen,RD;Liechty,KW;Koenig,JM;Schibler,KR;Ohls,RK
通讯作者：
Ohls,RK
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影响因子：
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作者：
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通讯作者：
D. K. Ganguly
贫血、非尿毒症患者的促红细胞生成素滴度。
DOI：
10.5555/uri:pii:0022214387901156
发表时间：
1987
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
A. Erslev;J. Wilson;J. Caro
通讯作者：
J. Caro