Cortical regions recruited for complex active-learning strategies and action planning exhibit rapid reactivation during memory retrieval.
Cortical regions recruited for complex active-learning strategies and action planning exhibit rapid reactivation during memory retrieval.
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DOI：
10.1016/j.neuropsychologia.2011.10.012
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发表时间：
2011-12
期刊：
影响因子：
2.6
通讯作者：
Gonsalves BD
中科院分区：
文献类型：
--
作者：
Voss JL;Galvan A;Gonsalves BD
记忆提取可以涉及与感知原始事件相同的感觉皮层区域的活动，并且这种神经“再激活”被认为是记忆提取的重要机制。然而，目前还不清楚，除了感官信息之外的经验片段是否被保留下来，并在提取过程中被重新激活。例如，在非实验室环境中的学习通常涉及对记忆的积极探索，因此需要为行为制定行动计划，并使用策略来提高随后的记忆表现。与行动计划和战略处理有关的信息是否在检索过程中保留和重新激活？为了解决这个问题，我们比较了ERP相关的记忆检索的对象，已经研究了在一个积极的方式，涉及行动规划和战略处理的对象，被动研究。记忆性能是上级积极研究的对象，和独特的ERP检索相关的这些对象被确定时，受试者记住的具体空间位置，对象进行了研究。早发性额叶移位的ERP相关检索注意到这些对象，平行招聘的额叶皮层在学习对象的位置，以前确定使用功能磁共振成像相同的范例。值得注意的是，ERP在回忆的项目研究与特定的观看策略定位到相同的辅助运动皮层区域，以前确定与功能磁共振成像时，这种策略是在研究过程中实施，这表明快速重新激活的区域直接参与战略行动规划。总的来说，这些结果暗示参与学习的神经群体在重要的检索功能，即使是那些参与战略控制和行动规划的人群。值得注意的是，这些情景特征在回忆性体验中通常不会被报告，这表明重新激活是记忆提取的一个更普遍的属性，它超出了那些可能需要重新生活过去的感知信息片段。
Memory retrieval can involve activity in the same sensory cortical regions involved in perception of the original event, and this neural “reactivation” has been suggested as an important mechanism of memory retrieval. However, it is still unclear if fragments of experience other than sensory information are retained and later reactivated during retrieval. For example, learning in non-laboratory settings generally involves active exploration of memoranda, thus requiring the generation of action plans for behavior and the use of strategies deployed to improve subsequent memory performance. Is information pertaining to action planning and strategic processing retained and reactivated during retrieval? To address this question, we compared ERP correlates of memory retrieval for objects that had been studied in an active manner involving action planning and strategic processing to those for objects that had been studied passively. Memory performance was superior for actively studied objects, and unique ERP retrieval correlates for these objects were identified when subjects remembered the specific spatial locations at which objects were studied. Early-onset frontal shifts in ERP correlates of retrieval were noted for these objects, which parallel the recruitment of frontal cortex during learning object locations previously identified using fMRI with the same paradigm. Notably, ERPs during recall for items studied with a specific viewing strategy localized to the same supplementary motor cortex region previously identified with fMRI when this strategy was implemented during study, suggesting rapid reactivation of regions directly involved in strategic action planning. Collectively, these results implicate neural populations involved in learning in important retrieval functions, even for those populations involved in strategic control and action planning. Notably, these episodic features are not generally reported during recollective experiences, suggesting that reactivation is a more general property of memory retrieval that extends beyond those fragments of perceptual information that might be needed to re-live the past.
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