Objectively Measured Total Sedentary Time and Pattern of Sedentary Accumulation in Older Adults: Associations With Incident Cardiovascular Disease and All-Cause Mortality.
Objectively Measured Total Sedentary Time and Pattern of Sedentary Accumulation in Older Adults: Associations With Incident Cardiovascular Disease and All-Cause Mortality.
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DOI：
10.1093/gerona/glac023
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发表时间：
2022-04-01
期刊：
影响因子：
--
通讯作者：
Sabia S
中科院分区：
文献类型：
--
作者：
Yerramalla MS;van Hees VT;Chen M;Fayosse A;Chastin SFM;Sabia S
我们研究了客观测量的久坐行为（SB）的总持续时间和累积模式与老年人心血管疾病（CVD）和全因死亡率的关系。从2012-2013年3991名60-83岁的白厅II研究参与者的加速度计数据中提取了总久坐时间和8个久坐累积模式指标。确定了截至2019年3月的CVD事件和全因死亡率。在平均（标准差[SD]）6.2（1.3）年和6.4（0.8）年的随访中，分别记录了299例CVD病例和260例死亡。调整社会人口统计学和行为因素后，总久坐时间增加1-SD（100.2分钟）与CVD风险增加20%相关（风险比[95%置信区间]：1.20 [1.05-1.37]）。更多的碎片SB与CVD风险降低相关（例如，每静坐1小时的休息时间增加1-SD [6.2]，为0.86 [0.76-0.97]）。一旦考虑到健康相关因素和中等至剧烈的体力活动（MVPA），相关性就不明显了。对于全因死亡率，仅在最年轻的老年组（<74岁;与年龄相互作用的p <0.01）中发现了与更多碎片SB（例如，每静坐一小时的休息时间为0.73 [0.59-0.91]）的相关性，与所有协变量无关。在这项研究中，一旦考虑MVPA，在总样本中未发现总久坐时间和久坐累积模式与CVD事件和全因死亡率的相关性。我们的研究结果表明，在<74岁的个体中，死亡风险降低，总SB减少，更分散的SB独立于MVPA，需要复制，以支持最近的建议，以减少SB和片段。
We examined associations of total duration and pattern of accumulation of objectively measured sedentary behavior (SB) with incident cardiovascular disease (CVD) and all-cause mortality among older adults. Total sedentary time and 8 sedentary accumulation pattern metrics were extracted from accelerometer data of 3 991 Whitehall II study participants aged 60–83 years in 2012–2013. Incident CVD and all-cause mortality were ascertained up to March 2019. Two hundred and ninety-nine CVD cases and 260 deaths were recorded over a mean (standard deviation [SD]) follow-up of 6.2 (1.3) and 6.4 (0.8) years, respectively. Adjusting for sociodemographic and behavioral factors, 1-SD (100.2 minutes) increase in total sedentary time was associated with 20% higher CVD risk (hazard ratio [95% confidence interval]: 1.20 [1.05–1.37]). More fragmented SB was associated with reduced CVD risk (eg, 0.86 [0.76–0.97] for 1-SD [6.2] increase in breaks per sedentary hour). Associations were not evident once health-related factors and moderate-to-vigorous physical activity (MVPA) were considered. For all-cause mortality, associations with more fragmented SB (eg, 0.73 [0.59–0.91] for breaks per sedentary hour) were found only among the youngest older group (<74 years; p for interaction with age < .01) independently from all covariates. In this study, no associations of total sedentary time and sedentary accumulation patterns with incident CVD and all-cause mortality were found in the total sample once MVPA was considered. Our findings of reduced mortality risk with less total and more fragmented SB independent from MVPA among individuals <74 years need to be replicated to support the recent recommendations to reduce and fragment SB.
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影响因子：
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