Anti-tumor effect of non-steroidal anti-inflammatory drugs on human ovarian cancers
Anti-tumor effect of non-steroidal anti-inflammatory drugs on human ovarian cancers
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非甾体抗炎药对人卵巢癌的抗肿瘤作用
DOI：
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发表时间：
2008
影响因子：
2.8
通讯作者：
H. Mizunuma
中科院分区：
文献类型：
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作者：
B. Xin;Y. Yokoyama;T. Shigeto;H. Mizunuma
许多报道表明，非甾体抗炎药（NSAIDs）具有抑制恶性转化和肿瘤生长的作用，一些NSAIDs有望成为新的抗癌药物。在这项研究中，我们检测了非特异性环氧化酶（COX）抑制剂阿司匹林和吡罗西康以及选择性COX-2抑制剂美洛昔康对异种移植卵巢癌的抗肿瘤作用。研究人员比较了雌性nu/nu小鼠的肿瘤生长和存活情况，这些小鼠皮下移植OVCAR-3肿瘤或腹腔内移植DISS肿瘤，并给予阿司匹林（每日200 ppm）、吡罗西康（每日150 ppm）或美洛昔康（每日162 ppm）治疗。与对照组相比，测试的药物中有一种显著抑制了OVCAR-3肿瘤异种皮下移植的生长。美洛昔康与阿司匹林治疗对OVCAR-3肿瘤生长的抑制有显著差异。与对照组和阿司匹林治疗相比，美洛昔康和吡罗昔康治疗显著延长了DISS细胞恶性腹水小鼠的存活时间。用美洛昔康治疗的小鼠存活时间明显长于用吡罗西康治疗的小鼠。对照组和阿司匹林治疗组的生存率无显著差异。尸检显示，在给予吡罗西康治疗的6只患癌小鼠中，有一只出现了胃穿孔。这些结果表明，选择性COX-2抑制剂比非选择性COX抑制剂对卵巢癌产生更大的抗肿瘤作用，并且美洛昔康可能有可能导致一种新的卵巢癌治疗策略。
Many reports have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) suppress malignant transformation and tumor growth, and some NSAIDs are expected to be new anti-cancer agents. In this study, we examined the anti-tumor effects of the non-specific cyclooxygenase (COX) inhibitors aspirin and piroxicam, and the selective COX-2 inhibitor meloxicam on xenotransplanted ovarian cancer. Tumor growth and survival were compared in female nu/nu mice, xenografted with subcutaneous OVCAR-3 tumors or with intraperitoneal DISS tumors and treated with aspirin (200 ppm in diet, everyday), piroxicam (150 ppm in diet, everyday) or meloxicam (162 ppm in diet, everyday). Al, of the agents tested significantly suppressed the growth of OVCAR-3 tumors xenotransplanted subcutaneously as compared to the control. There was a significant difference in inhibition of OVCAR-3 tumor growth between meloxicam and aspirin treatment. Meloxicam and piroxicam treatment significantly prolonged survival of mice with malignant ascites derived from DISS cells as compared to control and aspirin treatment. Mice treated with meloxicam survived significantly longer than those treated with piroxicam. There was no significant difference in survival between control and aspirin treatment. Necropsy revealed that one of the 6 cancer-bearing mice treated with piroxicam suffered from stomach perforation. These results indicate that a selective COX-2 inhibitor produces greater anti-tumor effect against ovarian cancer than a nonselective COX inhibitor and that meloxicam may have a potential of leading to a novel therapeutic strategy against ovarian cancer.
吡罗昔康治疗的终止和氧化偶氮甲烷诱导的大鼠结肠癌的发生。
影响因子：
9.7
作者：
Li,H;Kramer,PM;Lubet,RA;Steele,VE;Kelloff,GJ;Pereira,MA
通讯作者：
Pereira,MA
影响因子：
4.7
作者：
Goldman, AP;Williams, CS;DuBois, RN
通讯作者：
DuBois, RN
影响因子：
5.1
作者：
Akhmedkhanov, A;Toniolo, P;Shore, RE
通讯作者：
Shore, RE