Imaging intelligence with proton magnetic resonance spectroscopy.

Imaging intelligence with proton magnetic resonance spectroscopy.
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DOI:
10.1016/j.intell.2008.10.009
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发表时间:
2009-03-01
期刊:
影响因子:
3
通讯作者:
Yeo, Ronald A.
Yeo, Ronald A.
中科院分区:
心理学2区
文献类型:
--
作者:
Jung, Rex E.;Gasparovic, Charles;Chavez, Robert S.;Caprihan, Arvind;Barrow, Ranee;Yeo, Ronald A.

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质子磁共振波谱(1H-MRS)是一种用于体内脑神经化学分析的技术。N-乙酰天冬氨酸(NAA)是1H-MRS谱中可见的最主要代谢物,主要存在于神经元内。目前的研究旨在进一步阐明NAA认知的关系,特别是这种关系是否是由性别,或组织类型(灰色或白色物质)主持。我们对63名年轻健康的受试者进行了标准的智力测量,并在侧脑室上级组织板内获得了光谱成像数据。我们发现,右前灰质内NAA越低,VIQ表现越好(F=6.83,p=.011,r2=.10),而右后灰质内NAA越高,PIQ表现越好(F=8.175,p=.006,r2=.12)。这些发现增加了小,但越来越多的文献连接大脑生物化学的智力在正常健康受试者使用1H-MRSI。
Proton magnetic resonance spectroscopy (1H-MRS) is a technique for the assay of brain neurochemistry in vivo. N-acetylaspartate (NAA), the most prominent metabolite visible within the 1H-MRS spectrum, is found primarily within neurons. The current study was designed to further elucidate NAA–cognition relationships, particularly whether such relationships are moderated by sex, or tissue type (gray or white matter). We administered standard measures of intelligence to 63 young, healthy subjects and obtained spectroscopic imaging data within a slab of tissue superior to the lateral ventricles. We found that lower NAA within right anterior gray matter predicted better performance VIQ (F=6.83, p=.011, r2=.10), while higher NAA within the right posterior gray matter region predicted better PIQ (F=8.175, p=.006, r2=.12). These findings add to the small but growing body of literature linking brain biochemistry to intelligence in normal healthy subjects using 1H-MRSI.
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