Effects of Chili Treatment on Gastrointestinal and Rectal Sensation in Diarrhea-predominant Irritable Bowel Syndrome: A Randomized, Double-blinded, Crossover Study.
Effects of Chili Treatment on Gastrointestinal and Rectal Sensation in Diarrhea-predominant Irritable Bowel Syndrome: A Randomized, Double-blinded, Crossover Study.
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DOI：
10.5056/jnm14022
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发表时间：
2014-07-31
影响因子：
3.4
通讯作者：
Gonlachanvit S
中科院分区：
文献类型：
--
作者：
Aniwan S;Gonlachanvit S
在腹泻型肠易激综合征(IBS-D)患者中，长期摄入辣椒是否会使胃肠(GI)中瞬时受体潜在的香草素1型受体脱敏，从而导致GI症状和感觉下降，尚未得到很好的研究。本研究的目的是确定6周的辣椒治疗对IBS-D患者餐后胃肠道症状和直肠感觉的影响。16名IBS-D患者在餐前服用安慰剂或辣椒胶囊，每天3次，连续6周，采用随机、双盲、交叉方式，为期4周。评估餐后胃肠道症状。所有患者在每次治疗结束时都接受了直肠恒压研究，以评估直肠感觉阈值。两组的餐后最大腹痛评分在基线时相似(1.4[0.0-2.0]vs.1.1[0.0-2.8]，P>；0.05)，但在治疗结束时，服用辣椒后显著降低(0.0[0.0-0.5]vs.0.3[0.0-1.6]，P<；0.05)。辣椒治疗显著提高了第一次直肠感觉的感觉阈值(中位数[四分位数范围]：16[12-16]mm Hg比8[8-16]mm Hg，P<；0.05)，但对直肠顺应性(7.3±1.0比7.1±1.8 m L/mm Hg)没有显著影响。在基线和治疗结束时，两种治疗方法之间的其他餐后胃肠道症状没有显著差异。在IBS-D患者中，6周的辣椒摄入显著减少了餐后腹部灼热感，并提高了直肠感觉阈值。这些发现表明，摄入辣椒对近端肠道和直肠的瞬时受体电位香草素1型受体具有脱敏作用。
Whether, chronic chili ingestion can desensitize transient receptor potential vanilloid type 1 receptors in gastrointestinal (GI) tract leading to decrease GI symptoms and sensation in diarrhea-predominant irritable bowel syndrome (IBS-D) patients has not been well explored. The aim of this study was to determine the effects of 6-week chili treatment on postprandial GI symptoms and rectal sensation in response to balloon distention in IBS-D patients. Sixteen IBS-D patients received placebo or chili capsules before meals 3 times/day for 6 weeks in a randomized, double-blinded, crossover fashion with 4-week washout period. Postprandial GI symptoms were evaluated. All patients underwent a rectal barostat study to evaluate rectal sensory threshold at the end of each treatment. The maximum postprandial abdominal burning scores were similar between both treatments at baseline (1.4 [0.0–2.0] vs. 1.1 [0.0–2.8], P > 0.05) but were significantly decreased after chili (0.0 [0.0–0.5] vs. 0.3 [0.0–1.6], P < 0.05) at the end of treatment. The chili treatment significantly increased sensory threshold for the first rectal sensation (median [interquartile range]:16 [12–16] mmHg vs. 8 [8–16] mmHg, P < 0.05) however, there was no significant effect on rectal compliance (7.3 ± 1.0 vs. 7.1 ± 1.8 mL/mmHg). Other postprandial GI symptoms did not vary significantly between both treatments at baseline and the end of treatment. In IBS-D patients, 6-week chili ingestion significantly decreased postprandial abdominal burning and increased the rectal sensory threshold. These findings suggest a desensitization effect of chili ingestion on transient receptor potential vanilloid type 1 receptors in the proximal gut and rectum.
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