Distinct roles of rodent orbitofrontal and medial prefrontal cortex in decision making.
Distinct roles of rodent orbitofrontal and medial prefrontal cortex in decision making.
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DOI:
10.1016/j.neuron.2010.03.033
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发表时间:
2010-05-13
期刊:
影响因子:
16.2
通讯作者:
Jung, Min Whan
中科院分区:
文献类型:
--
作者:
Sul, Jung Hoon;Kim, Hoseok;Huh, Namjung;Lee, Daeyeol;Jung, Min Whan
We investigated how different sub-regions of rodent prefrontal cortex contribute to value-based decision making, by comparing neural signals related to animal’s choice, its outcome, and action value in orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) of rats performing a dynamic two-armed bandit task. Neural signals for upcoming action selection arose in the mPFC, including the anterior cingulate cortex, only immediately before the behavioral manifestation of animal’s choice, suggesting that rodent prefrontal cortex is not involved in advanced action planning. Both OFC and mPFC conveyed signals related to the animal’s past choices and their outcomes over multiple trials, but neural signals for chosen value and reward prediction error were more prevalent in the OFC. Our results suggest that rodent OFC and mPFC serve distinct roles in value-based decision making, and that the OFC plays a prominent role in updating the values of outcomes expected from chosen actions.
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影响因子:
3.2
作者:
Kennerley SW;Dahmubed AF;Lara AH;Wallis JD
通讯作者:
Wallis JD
影响因子:
64.8
作者:
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者:
Dolan, Raymond J.
DOI:
10.1196/annals.1390.007
发表时间:
2007-01-01
期刊:
REWARD AND DECISION MAKING IN CORTICOBASAL GANGLIA NETWORKS
影响因子:
--
作者:
Lee, Daeyeol;Seo, Hyojung
通讯作者:
Seo, Hyojung
影响因子:
5.3
作者:
Kim, Hoseok;Sul, Jung Hoon;Jung, Min Whan
通讯作者:
Jung, Min Whan
DOI:
10.1111/j.1460-9568.2009.06743.x
发表时间:
2009-05
期刊:
The European journal of neuroscience
影响因子:
--
作者:
Kennerley SW;Wallis JD
通讯作者:
Wallis JD