Distinct roles of rodent orbitofrontal and medial prefrontal cortex in decision making.

Distinct roles of rodent orbitofrontal and medial prefrontal cortex in decision making.
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DOI:
10.1016/j.neuron.2010.03.033
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发表时间:
2010-05-13
期刊:
影响因子:
16.2
通讯作者:
Jung, Min Whan
Jung, Min Whan
中科院分区:
医学1区
文献类型:
--
作者:
Sul, Jung Hoon;Kim, Hoseok;Huh, Namjung;Lee, Daeyeol;Jung, Min Whan

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我们通过比较执行动态双臂老虎机任务的大鼠的眶额皮层 (OFC) 和内侧前额叶皮层 (mPFC) 中与动物选择、结果和动作价值相关的神经信号,研究了啮齿类动物前额叶皮层的不同子区域如何促进基于价值的决策。仅在动物选择的行为表现之前,mPFC(包括前扣带皮层)中才会出现即将采取的行动选择的神经信号,这表明啮齿类动物的前额叶皮层不参与高级行动计划。 OFC 和 mPFC 都传递与动物过去的选择及其在多次试验中的结果相关的信号,但选择值和奖励预测误差的神经信号在 OFC 中更为普遍。我们的研究结果表明,啮齿动物 OFC 和 mPFC 在基于价值的决策中发挥着不同的作用,并且 OFC 在更新所选行动预期结果的价值方面发挥着重要作用。
We investigated how different sub-regions of rodent prefrontal cortex contribute to value-based decision making, by comparing neural signals related to animal’s choice, its outcome, and action value in orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) of rats performing a dynamic two-armed bandit task. Neural signals for upcoming action selection arose in the mPFC, including the anterior cingulate cortex, only immediately before the behavioral manifestation of animal’s choice, suggesting that rodent prefrontal cortex is not involved in advanced action planning. Both OFC and mPFC conveyed signals related to the animal’s past choices and their outcomes over multiple trials, but neural signals for chosen value and reward prediction error were more prevalent in the OFC. Our results suggest that rodent OFC and mPFC serve distinct roles in value-based decision making, and that the OFC plays a prominent role in updating the values of outcomes expected from chosen actions.
额叶中的神经元编码多个决策变量的值。
DOI: 10.1162/jocn.2009.21100
发表时间: 2009-06
影响因子: 3.2
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发表时间: 2009-05
期刊: The European journal of neuroscience
影响因子: --
作者:
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通讯作者: Wallis JD