Essential immunologic orchestrators of intestinal homeostasis.
Essential immunologic orchestrators of intestinal homeostasis.
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DOI：
10.1126/sciimmunol.aao1605
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发表时间：
2018-02-09
影响因子：
24.8
通讯作者：
Sonnenberg GF
中科院分区：
文献类型：
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作者：
Zhou L;Sonnenberg GF
在过去的25年里，我们对维持哺乳动物胃肠道健康状态所必需的细胞和分子途径的理解取得了重大进展，胃肠道是一个密集地定植着免疫细胞和数万亿微生物的器官。20世纪90年代的开创性研究发现，几种细胞因子、抗原呈递分子和T细胞受体的成分是防止小鼠自发肠道炎症发展所必需的。随后的研究表明，这些途径协调了与肠道微生物的有益相互作用，涉及先天和适应性免疫细胞之间的复杂通信，并可能在人类炎症性肠病中失调。在这里，我们讨论了这些早期发现如何为许多其他进展奠定了基础，并塑造了我们目前对哺乳动物宿主-微生物群相互作用和肠道稳态的认识。预计对这些领域的持续研究将确定肠道耐受和炎症的新的免疫机制，这些机制可以被利用来造福人类健康。这篇综述讨论了开创性的发现如何塑造了我们目前对哺乳动物肠道免疫稳态和宿主-微生物群相互作用的理解。
Over the past 25 years, substantial advances have been made in our understanding of the cellular and molecular pathways that are essential to maintain a state of health in the mammalian gastrointestinal tract, an organ that is densely colonized with both immune cells and trillions of microbes. Seminal studies in the 1990’s identified that several cytokines, antigen-presentation molecules, and components of the T cell receptor were necessary to prevent the development of spontaneous intestinal inflammation in mice. Subsequent research revealed that these pathways orchestrate beneficial interactions with intestinal microbes, involve complex communication between innate and adaptive immune cells, and can be dysregulated in human inflammatory bowel disease. Here we discuss how these early findings set the stage for numerous other advances and shaped our current knowledge of host-microbiota interactions and intestinal homeostasis in mammals. It is expected that continued investigation of these areas will define novel immunologic mechanisms of tolerance and inflammation in the intestine that can be exploited to benefit human health. This review discusses how seminal findings have shaped our current understanding of immunologic homeostasis and host-microbiota interactions in the mammalian intestine.
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影响因子：
32.4
作者：
Fung TC;Bessman NJ;Hepworth MR;Kumar N;Shibata N;Kobuley D;Wang K;Ziegler CGK;Goc J;Shima T;Umesaki Y;Sartor RB;Sullivan KV;Lawley TD;Kunisawa J;Kiyono H;Sonnenberg GF
通讯作者：
Sonnenberg GF
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
29.4
作者：
Benchimol, Eric I.;Mack, David R.;Muise, Aleixo M.
通讯作者：
Muise, Aleixo M.
影响因子：
30.5
作者：
Bernink, Jochem H.;Peters, Charlotte P.;Spits, Hergen
通讯作者：
Spits, Hergen
影响因子：
64.8
作者：
通讯作者：
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