DRodVir: A resource for exploring the virome diversity in rodents.
DRodVir: A resource for exploring the virome diversity in rodents.
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DOI：
10.1016/j.jgg.2017.04.004
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发表时间：
2017-05-20
期刊：
影响因子：
--
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Chen L;Liu B;Wu Z;Jin Q;Yang J
近年来，新发人畜共患病引起了人们极大的兴趣，因为它们对人类健康、动物福利和经济稳定构成了重大威胁。很大一部分人畜共患病起源于野生动物宿主。啮齿动物是地球上数量最多、分布最广、种类最多的哺乳动物，也是许多人畜共患病毒的宿主，这些病毒可导致显著的发病率和死亡率。更好地了解啮齿动物病毒组的多样性将是重要的研究人员和专业人员在该领域。因此，我们开发了DRodVir数据库（http：//www.mgc.ac.cn/DRodVir/），这是一个全面的、最新的、精心策划的啮齿动物相关动物病毒库。该数据库目前涵盖了来自全球93个国家的194种啮齿动物中检测到的26个病毒家族的5491种啮齿动物相关哺乳动物病毒的7690个序列。除了病毒序列外，该数据库还提供相关样本和宿主啮齿动物的详细信息，以及一套用于文本查询、BLAST搜索和系统发育重建的在线分析工具。DRodVir数据库将帮助病毒学家更好地了解啮齿动物的病毒组多样性。此外，它将成为流行病学家和动物学家轻松监测和跟踪当前和未来人畜共患病的宝贵工具。作为一个数据应用实例，我们进一步比较了啮齿动物相关病毒和蝙蝠相关病毒的现状，以强调在未来调查中纳入其他宿主物种和地理区域的必要性，这将有助于我们更好地了解新出现的人畜共患传染病的两个主要宿主中的病毒组群。
Emerging zoonotic diseases have received tremendous interests in recent years, as they pose a significant threat to human health, animal welfare, and economic stability. A high proportion of zoonoses originate from wildlife reservoirs. Rodents are the most numerous, widespread, and diverse group of mammals on the earth and are reservoirs for many zoonotic viruses responsible for significant morbidity and mortality. A better understanding of virome diversity in rodents would be of importance for researchers and professionals in the field. Therefore, we developed the DRodVir database (http://www.mgc.ac.cn/DRodVir/), a comprehensive, up-to-date, and well-curated repository of rodent-associated animal viruses. The database currently covers 7690 sequences from 5491 rodent-associated mammal viruses of 26 viral families detected from 194 rodent species in 93 countries worldwide. In addition to virus sequences, the database provides detailed information on related samples and host rodents, as well as a set of online analytical tools for text query, BLAST search and phylogenetic reconstruction. The DRodVir database will help virologists better understand the virome diversity of rodents. Moreover, it will be a valuable tool for epidemiologists and zoologists for easy monitoring and tracking of the current and future zoonotic diseases. As a data application example, we further compared the current status of rodent-associated viruses with bat-associated viruses to highlight the necessity for including additional host species and geographic regions in future investigations, which will help us achieve a better understanding of the virome diversities in the two major reservoirs of emerging zoonotic infectious diseases.
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影响因子：
10.7
作者：
Huchon, D;Madsen, O;Douzery, EJP
通讯作者：
Douzery, EJP
影响因子：
64.8
作者：
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影响因子：
4.6
作者：
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通讯作者：
Bowen RA
野生动植物作为人畜共患感染的来源。
影响因子：
11.8
作者：
Kruse H;kirkemo AM;Handeland K
通讯作者：
Handeland K
影响因子：
64.8
作者：
Ge XY;Li JL;Yang XL;Chmura AA;Zhu G;Epstein JH;Mazet JK;Hu B;Zhang W;Peng C;Zhang YJ;Luo CM;Tan B;Wang N;Zhu Y;Crameri G;Zhang SY;Wang LF;Daszak P;Shi ZL
通讯作者：
Shi ZL