4D Printing of shape-memory polymeric scaffolds for adaptive biomedical implantation.
4D Printing of shape-memory polymeric scaffolds for adaptive biomedical implantation.
复制标题
DOI：
10.1016/j.actbio.2020.12.042
复制
发表时间：
2021-03-01
影响因子：
9.7
通讯作者：
Lin J
中科院分区：
文献类型：
--
作者：
Zhang C;Cai D;Liao P;Su JW;Deng H;Vardhanabhuti B;Ulery BD;Chen SY;Lin J
由于制造设备的适应性和最小的侵入性，4D打印在各种生物医学应用中显示出巨大的潜力。然而，通常使用的形状记忆聚合物（SMPs）具有不理想的转变温度（ttrans），导致植入手术的并发症。在此，我们展示了一种名为聚（甘油十二酸酯）丙烯酸酯（PGDA）的新型SMP在20°C - 37°C的范围内与Ttrans进行4D打印，使其适合在室温下进行形状编程，然后在人体内进行形状部署。此外，该材料具有合适的流变特性，可以制造各种精致的3D结构，如“三角星”、“六瓣花”、“蜂窝”、“管”、倾斜的“截断空心锥”，以及悬垂的“桥”、“笼”和“网”。打印的3D结构具有形状记忆性能，包括在20°C时具有100%的大固定性，在37°C时具有98%的大回复率，> 100次的稳定循环性，以及在37°C时具有0.4 s的快速恢复速度。此外，由于PGDA的相变，打印结构的杨氏模量可以降低5倍，与生物组织兼容。最后，体外支架植入和体内血管移植实验证明了打印构建体在生物医学植入中的几何和力学适应性。这种新开发的基于PGDA SMP的4D打印技术有可能为个性化生物医学应用的形状记忆支架的制造铺平新的道路。
4D printing has shown great potential in a variety of biomedical applications due to the adaptability and minimal invasiveness of fabricated devices. However, commonly employed shape memory polymers (SMPs) possess undesirable transition temperatures (Ttranss), leading to complications in implantation operations. Herein, we demonstrate 4D printing of a new SMP named poly(glycerol dodecanoate) acrylate (PGDA) with a Ttrans in a range of 20 °C - 37 °C making it appropriate for shape programming at room temperature and then shape deployment within the human body. In addition, the material possesses suitable rheological properties to allow for the fabrication of a variety of delicate 3D structures such as “triangular star”, “six-petal flower”, “honeycomb”, “tube”, tilted “truncated hollow cones”, as well as overhanging “bridge”, “cage”, and “mesh”. The printed 3D structures show shape memory properties including a large fixity ratio of 100% at 20 °C, a large recovery ratio of 98% at 37 °C, a stable cyclability of > 100 times, and a fast recovery speed of 0.4 s at 37 °C. Moreover, the Young’s moduli of the printed structures can be decreased by 5 times due to the phase transition of PGDA, which is compatible with biological tissues. Finally, in vitro stenting and in vivo vascular grafting demonstrated the geometrical and mechanical adaptivity of the printed constructs for biomedical implantation. This newly developed PGDA SMP based 4D printing technology has the potential to pave a new route to the fabrication of shape memory scaffolds for personalized biomedical applications.
登录
查看更多内容
DOI：
10.1002/jbm.a.35973
发表时间：
2017-06
期刊：
Journal of biomedical materials research. Part A
影响因子：
--
作者：
Solorio LD;Bocks ML;Hollister SJ
通讯作者：
Hollister SJ
影响因子：
14
作者：
Migneco, Francesco;Huang, Yen-Chih;Birla, Ravi K.;Hollister, Scott J.
通讯作者：
Hollister, Scott J.
影响因子：
10
作者：
Placone JK;Engler AJ
通讯作者：
Engler AJ
影响因子：
9.5
作者：
Kuang, Xiao;Chen, Kaijuan;Qi, H. Jerry
通讯作者：
Qi, H. Jerry
影响因子：
41.2
作者：
Montgomery, Miles;Ahadian, Samad;Radisic, Milica
通讯作者：
Radisic, Milica