Processing of harmonics in the lateral belt of macaque auditory cortex.
Processing of harmonics in the lateral belt of macaque auditory cortex.
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DOI：
10.3389/fnins.2014.00204
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发表时间：
2014
影响因子：
4.3
通讯作者：
Rauschecker JP
中科院分区：
文献类型：
--
作者：
Kikuchi Y;Horwitz B;Mishkin M;Rauschecker JP
许多说话的声音和动物的发声都包含被称为复杂音调的成分，它由一个基本频率（F0）和更高的谐波组成。在这项研究中，我们检测了两只恒河猴在听纯音和同音异音（“coos”）时，听觉皮层核心（A1）和侧带（LB）区域记录的单单元活动。后者由复音片段组成，其中F0与相应的纯音刺激相匹配。在两种动物中，LB组的神经元对最佳频率（BF）纯音刺激的潜伏期比A1组长10 ~ 15 ms。这可能是意料之中的，因为LB被认为在层次上比A1更高。另一方面，与对相应的纯音BF的反应相比，LB对coos的反应潜伏期约短10 ~ 20 ms，表明谐波对LB的促进作用。在A1中没有观察到这种延迟减少，导致A1和LB中相似的延迟。A1和LB中都存在多峰神经元；然而，在LB中，早期和晚期反应成分均观察到谐波相关峰，而在A1中，仅在晚期反应成分中观察到谐波相关峰。我们的研究结果表明，谐波特征，如交流呼叫的特定频率间隔之间的关系，在听觉皮层通路的相对早期阶段被处理，但优先在LB处理。
Many speech sounds and animal vocalizations contain components, referred to as complex tones, that consist of a fundamental frequency (F0) and higher harmonics. In this study we examined single-unit activity recorded in the core (A1) and lateral belt (LB) areas of auditory cortex in two rhesus monkeys as they listened to pure tones and pitch-shifted conspecific vocalizations (“coos”). The latter consisted of complex-tone segments in which F0 was matched to a corresponding pure-tone stimulus. In both animals, neuronal latencies to pure-tone stimuli at the best frequency (BF) were ~10 to 15 ms longer in LB than in A1. This might be expected, since LB is considered to be at a hierarchically higher level than A1. On the other hand, the latency of LB responses to coos was ~10 to 20 ms shorter than to the corresponding pure-tone BF, suggesting facilitation in LB by the harmonics. This latency reduction by coos was not observed in A1, resulting in similar coo latencies in A1 and LB. Multi-peaked neurons were present in both A1 and LB; however, harmonically-related peaks were observed in LB for both early and late response components, whereas in A1 they were observed only for late components. Our results suggest that harmonic features, such as relationships between specific frequency intervals of communication calls, are processed at relatively early stages of the auditory cortical pathway, but preferentially in LB.
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DOI：
10.1523/jneurosci.0767-11.2012
发表时间：
2012-02-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Niwa M;Johnson JS;O'Connor KN;Sutter ML
通讯作者：
Sutter ML
影响因子：
2.5
作者：
Bartlett, Edward L.;Wang, Xiaoqin
通讯作者：
Wang, Xiaoqin
影响因子：
4.8
作者：
McLaren, Donald G.;Kosmatka, Kristopher J.;Kastman, Erik K.;Bendlin, Barbara B.;Johnson, Sterling C.
通讯作者：
Johnson, Sterling C.
DOI：
10.1523/jneurosci.2267-10.2010
发表时间：
2010-09-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kikuchi Y;Horwitz B;Mishkin M
通讯作者：
Mishkin M
影响因子：
2.4
作者：
Jackson, LL;Heffner, RS;Heffner, HE
通讯作者：
Heffner, HE