Serum visfatin concentration in acutely ill and weight-recovered patients with anorexia nervosa
Serum visfatin concentration in acutely ill and weight-recovered patients with anorexia nervosa
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神经性厌食症急性病患者和体重恢复患者的血清内脂素浓度
DOI：
10.1016/j.psyneuen.2014.12.010
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发表时间：
2015
影响因子：
3.7
通讯作者：
Ehrlich S
中科院分区：
文献类型：
--
作者：
Seidel M;King JA;Ritschel F;Döpmann J;Bühren K;Seitz J;Roessner V;Westphal S;Egberts K;Burghardt R;Wewetzer C;Fleischhaker V;Hebebrand J;Herpertz-Dahlmann B;Ehrlich S
内脂素是最近发现的一种调节脂肪细胞分化过程的蛋白质。研究结果表明，内脂素可能积极参与体重调节网络的控制。然而，在何种程度上，它在饮食失调中发挥的作用仍然知之甚少，因为报告的结果喜忧参半。本研究的目的是调查急性神经性厌食症患者（n= 44），体重恢复患者（n= 13）和健康对照组（n= 46）之间的横断面样本和急性患者（n= 57）在体重恢复期间在三个不同时间点的纵向样本的血清内脂素浓度。结果未显示三组间内脂素的显著差异;然而，急性患者的内脂素/BMI-SDS比值高于对照组和恢复患者。纵向结果显示治疗期间内脂素水平增加。我们的研究结果表明，高比例的内脂素/BMI-SDS可能是急性神经性厌食症的一个状态标志，显示了个体在营养不良条件下维持正常内脂素水平的代偿机制。
Visfatin is a recently described protein that is thought to regulate the process of adipocyte differentiation. Findings suggest that visfatin may be actively involved in the control of weight regulatory networks. However, to what extent and which role it plays in eating disorders is still poorly understood, as mixed results have been reported. The aim of the current study was to investigate serum visfatin concentrations on a cross sectional sample between acute anorexia nervosa patients (n= 44), weight recovered patients (n= 13) and healthy controls (n= 46) and a longitudinal sample of acute patients (n= 57) during weight recovery at three different time-points. Results did not show significant differences in visfatin between the three groups; however, acute patients showed a higher visfatin/BMI-SDS ratio than controls and recovered patients. Longitudinal results revealed an increase of visfatin levels during therapy. Our results suggest that high ratios of visfatin/BMI-SDS could be a state marker in acute anorexia nervosa, displaying a compensatory mechanism of the individual to maintain normal visfatin levels under malnourished conditions.
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影响因子：
3.6
作者：
Barth, Stephanie;Klein, Peter;Knerr, Ina
通讯作者：
Knerr, Ina
影响因子：
168.9
作者：
Herpertz-Dahlmann, Beate;Schwarte, Reinhild;Dempfle, Astrid
通讯作者：
Dempfle, Astrid
影响因子：
5.8
作者：
Manco, Melania;Fernandez-Real, J. Manuel;Mingrone, Geltrude
通讯作者：
Mingrone, Geltrude
[德国版饮食失调清单 EDI-2]。
DOI：
--
发表时间：
1997
期刊：
PPmP. Psychotherapie, Psychosomatik, medizinische Psychologie
影响因子：
--
作者：
A. Thiel;C. Jacobi;S. Horstmann;T. Paul;D. Nutzinger;G. Schüssler
通讯作者：
G. Schüssler
影响因子：
6.9
作者：
Araki, Shunsuke;Dobashi, Kazushige;Shirahata, Akira
通讯作者：
Shirahata, Akira