Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats.
Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats.
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DOI：
10.1016/j.psyneuen.2011.04.015
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发表时间：
2012-01
影响因子：
3.7
通讯作者：
McEwen, Bruce S.
中科院分区：
文献类型：
--
作者：
Eiland, Lisa;Ramroop, Johnny;Hill, Matthew N.;Manley, Jasmine;McEwen, Bruce S.
近12%的美国儿童暴露在强烈的不良经历中。研究表明，这些经历会对成年人的健康产生负面影响，通常会导致精神病理。然而，对儿童不良经历对儿童健康和福祉的影响的关注较少。利用幼年慢性应激的啮齿动物模型(从出生后第20天至41天每天束缚6小时)，我们报告了在这一发育窗口期，慢性应激对雄性和雌性都有显著的即刻发病率。具体地说，我们证明了慢性青少年应激会产生抑郁样行为，并对可能参与这些行为改变的大脑区域进行显著的神经元重塑：海马体、前额叶皮质和杏仁核。长期应激的男性和女性表现出快感缺失，在接触新奇事物时会增加行动能力，在面临严重压力时会改变应对策略。与这些行为变化一致，我们报告了海马体和前额叶皮质中树突的简化和杏仁核中树突的同时肥大。综上所述，这些结果表明，长期应激的青少年对急性挑战表现出异常的行为反应，这些挑战伴随着压力诱导的大脑区域重塑，这些区域与调节情绪性和应激反应密切相关。此外，我们报告的压力反应中没有性别差异，这可能说明未成熟的HPA调节大脑区域对性激素的敏感度降低。
Nearly 12% of US children are exposed to intense adverse experiences. Research has demonstrated that these experiences can negatively impact adult health, often resulting in psychopathology. Less attention, however, is given to the impact of childhood adverse experiences on childhood health and wellbeing. Using a rodent model of chronic juvenile stress (restraint 6h daily from postnatal day 20–41), we report that chronic stress has significant immediate morbidities in both males and females during this developmental window. Specifically, we demonstrate that chronic juvenile stress produces depressive-like behavior and significant neuronal remodeling of brain regions likely involved in these behavioral alterations: the hippocampus, prefrontal cortex and amygdala. Chronically stressed males and females exhibit anhedonia, increased locomotion when exposed to novelty, and altered coping strategies when exposed to acute stress. Coincident with these behavioral changes, we report simplification of dendrites in the hippocampus and prefrontal cortex and concurrent hypertrophy of dendrites in the amygdala. Taken together, these results demonstrate that chronically stressed juveniles exhibit aberrant behavioral responses to acute challenges that occur in conjunction with stress-induced remodeling of brain regions intimately involved in regulating emotionality and stress reactivity. Further, the absence of sex differences in our reported stress responses, likely speaks to the decreased sensitivity of immature HPA regulating brain regions to sex hormones.
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影响因子：
3.5
作者：
Isgor, C;Kabbaj, M;Watson, SJ
通讯作者：
Watson, SJ
影响因子：
3.5
作者：
Barha, Cindy K.;Brummelte, Susanne;Galea, Liisa A. M.
通讯作者：
Galea, Liisa A. M.
影响因子：
3.7
作者：
Maslova, LN;Bulygina, VV;Markel, AL
通讯作者：
Markel, AL
影响因子：
2.3
作者：
Leussis, Melanie P.;Andersen, Susan L.
通讯作者：
Andersen, Susan L.
影响因子：
2.7
作者：
McCormick, C. M.;Smith, C.;Mathews, I. Z.
通讯作者：
Mathews, I. Z.