Neuroscience. Can oxytocin treat autism?

Neuroscience. Can oxytocin treat autism?
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DOI:
10.1126/science.aaa8120
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发表时间:
2015-02-20
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Barrett CE
Barrett CE
中科院分区:
其他
文献类型:
--
作者:
Young LJ;Barrett CE

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美国疾病控制和预防中心估计,在美国,自闭症谱系障碍(ASD)的患病率为每68名儿童中就有一名,但目前还没有治疗自闭症社交缺陷的药物。催产素是一种在下丘脑产生的天然脑肽,作为自闭症社交缺陷的潜在治疗方法,已受到相当大的关注。急性鼻腔内催产素可暂时增强ASD患者的社会认知、同理心和互惠。然而,最近的临床试验结果喜忧参半,这让业界质疑催产素是否能辜负炒作。
The U.S. Centers for Disease Control and Prevention estimates the prevalence of autism spectrum disorders (ASDs) to be 1 in 68 children in the United States, yet no drugs to treat the debilitating social deficits of ASD are available. Oxytocin, a natural brain peptide produced in the hypothalamus, has received considerable attention as a potential treatment for social deficits in ASD. Acute intranasal oxytocin temporarily enhances social cognition, empathy, and reciprocity in individuals with ASD . However, recent clinical trials have yielded mixed results, leaving the field questioning whether oxytocin can live up to the hype.
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