Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening.
Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening.
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DOI：
10.1126/sciadv.abd5393
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发表时间：
2021-01
期刊：
影响因子：
13.6
通讯作者：
Parker R
中科院分区：
文献类型：
--
作者：
Larremore DB;Wilder B;Lester E;Shehata S;Burke JM;Hay JA;Tambe M;Mina MJ;Parker R
检测灵敏度仅次于COVID-19筛查的频率和周转时间。COVID-19疫情已造成公共卫生危机。由于SARS-CoV-2可以从症状前、症状和无症状感染的个体传播，因此，强有力的人群筛查将促进社会的重新开放和病毒传播的控制，而病毒检测往往是这方面的核心。感染后，个体经历一段时间的潜伏期，在此期间病毒滴度太低而无法检测，随后是指数病毒生长，导致病毒载量和感染性达到峰值，并以滴度下降和清除结束。考虑到病毒载量动力学的模式，我们模拟了重复人群筛查的有效性，考虑了检测灵敏度、频率和样本到答案的报告时间。这些结果表明，有效的筛查在很大程度上取决于测试的频率和报告的速度，只有通过高测试灵敏度略有改善。因此，我们得出结论，筛查应优先考虑可及性、频率和样本到答案的时间;检测的分析限度应是次要的。
Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening. The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the reopening of societies and the control of virus spread will be facilitated by robust population screening, for which virus testing will often be central. After infection, individuals undergo a period of incubation during which viral titers are too low to detect, followed by exponential viral growth, leading to peak viral load and infectiousness and ending with declining titers and clearance. Given the pattern of viral load kinetics, we model the effectiveness of repeated population screening considering test sensitivities, frequency, and sample-to-answer reporting time. These results demonstrate that effective screening depends largely on frequency of testing and speed of reporting and is only marginally improved by high test sensitivity. We therefore conclude that screening should prioritize accessibility, frequency, and sample-to-answer time; analytical limits of detection should be secondary.
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