Studies on antigenic competition.
Studies on antigenic competition.
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DOI：
10.1084/jem.130.4.821
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发表时间：
1969-10-01
影响因子：
15.3
通讯作者：
SISKIND, GW
中科院分区：
文献类型：
--
作者：
BRODY, NI;SISKIND, GW
在半抗原系统中研究了抗原竞争。发现：（a）当使用较大剂量的抗原时，竞争程度更大。(b)抗原竞争似乎与载体分子无关。(c)在抗原竞争中产生的抗体的亲和力近似等于仅用一种抗原免疫的动物所形成的抗体的亲和力。(d)抗原竞争仅在两种抗原都被注射以流入相同的区域淋巴结时发生。结果表明，抗原竞争发生在局部的抗原刺激的网站，并不介导的循环因子，耐受性诱导，或抑制由于交叉反应抗体的合成。
Antigenic competition was studied in a haptenic system. It was found that: (a) The extent of competition is greater when larger doses of antigen are employed. (b) Antigenic competition appears to be independent of the carrier molecule. (c) The affinity of the antibody produced in antigenic competition is approximately equal to the affinity of antibody formed by animals immunized with only one antigen. (d) Antigenic competition only occurs when both antigens are injected so as to drain into the same regional lymph nodes. The results suggest that antigenic competition occurs locally at the site of antigen stimulation and is not mediated by a circulating factor, by tolerance induction, or by suppression due to synthesis of cross-reacting antibodies.
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DOI：
10.1073/pnas.46.11.1470
发表时间：
1960-01-01
影响因子：
11.1
作者：
VELICK, SF;PARKER, CW;EISEN, HN
通讯作者：
EISEN, HN
影响因子：
15.3
作者：
FISHMAN, M
通讯作者：
FISHMAN, M
影响因子：
15.3
作者：
EISEN, H N;KERN, M;NEWTON, W T;HELMREICH, E
通讯作者：
HELMREICH, E
DOI：
10.1159/000320504
发表时间：
1964-01-01
期刊：
PROGRESS IN ALLERGY
影响因子：
--
作者：
ADLER, FL
通讯作者：
ADLER, FL
影响因子：
15.3
作者：
BRODY, NI;WALKER, JG;SISKIND, GW
通讯作者：
SISKIND, GW