Therapeutic properties of green tea against environmental insults.
Therapeutic properties of green tea against environmental insults.
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DOI：
10.1016/j.jnutbio.2016.05.005
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Shen CL
中科院分区：
文献类型：
--
作者：
Chen L;Mo H;Zhao L;Gao W;Wang S;Cromie MM;Lu C;Wang JS;Shen CL
杀虫剂、烟雾、霉菌毒素、多氯联苯和砷是对人类最常见的环境毒素和毒物。这些毒素和毒物可能在分子(DNA、RNA或蛋白质)、细胞器(线粒体、溶酶体或膜)、细胞(生长抑制或细胞死亡)、组织、器官和系统水平上影响人类健康。反应性自由基的形成、脂质过氧化、炎症、遗传毒性、肝脏毒性、胚胎毒性、神经系统改变、细胞凋亡和致癌事件是环境毒素和毒物毒性作用的一些机制。绿茶是一种非氧化和非发酵的茶，含有几种多酚，包括绿茶儿茶素，在临床前研究中和在非常有限的临床试验中显示出对这些环境毒素和毒物的保护作用。这些保护作用是由抗氧化、抗炎、抗突变、肝脏和神经保护以及抗癌活性共同调节的。此外，绿茶还调节信号通路，包括核因子κB和ERK通路，保护线粒体膜电位，抑制caspase-3活性，下调促凋亡蛋白，诱导II相解毒途径。本文综述了绿茶的生物利用度和代谢，以及绿茶对农药、烟雾、真菌毒素、多氯联苯和砷等环境污染的保护作用。未来的研究应侧重于临床试验，确定绿茶摄入量的生物标志物，研究绿茶多酚的作用机制，并调查绿茶与其他毒物调节饮食因素的潜在相互作用。
Pesticides, smoke, mycotoxins, polychlorinated biphenyls, and arsenic are the most common environmental toxins and toxicants to humans. These toxins and toxicants may impact on human health at the molecular (DNA, RNA, or protein), organelle (mitochondria, lysosome, or membranes), cellular (growth inhibition or cell death), tissue, organ, and systemic levels. Formation of reactive radicals, lipid peroxidation, inflammation, genotoxicity, hepatotoxicity, embryotoxicity, neurological alterations, apoptosis, and carcinogenic events are some of the mechanisms mediating the toxic effects of the environmental toxins and toxicants. Green tea, the non-oxidized and non-fermented form of tea that contains several polyphenols, including green tea catechins, exhibits protective effects against these environmental toxins and toxicants in preclinical studies and to a much-limited extent, in clinical trials. The protective effects are collectively mediated by antioxidant, anti-inflammatory, anti-mutagenic, hepato- and neuroprotective, and anti-carcinogenic activities. In addition, green tea modulates signaling pathway including NFκB and ERK pathways, preserves mitochondrial membrane potential, inhibits caspase-3 activity, down-regulates pro-apoptotic proteins, and induces the phase II detoxifying pathway. The bioavailability and metabolism of green tea and its protective effects against environmental insults induced by pesticides, smoke, mycotoxins, polychlorinated biphenyls, and arsenic are reviewed in this paper. Future studies with emphasis on clinical trials should identify biomarkers of green tea intake, examine the mechanisms of action of green tea polyphenols, and investigate potential interactions of green tea with other toxicant-modulating dietary factors.
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影响因子：
4.7
作者：
Bose, Tanima
通讯作者：
Bose, Tanima
DOI：
10.1016/j.bpg.2014.08.007
发表时间：
2014-10-01
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.5
作者：
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