A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced inflammation in white adipose tissue and liver.
A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced inflammation in white adipose tissue and liver.
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DOI：
10.2337/db11-1688
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发表时间：
2012-08
期刊：
影响因子：
7.7
通讯作者：
Yoshimatsu H
中科院分区：
文献类型：
--
作者：
Gotoh K;Inoue M;Masaki T;Chiba S;Shimasaki T;Ando H;Fujiwara K;Katsuragi I;Kakuma T;Seike M;Sakata T;Yoshimatsu H
肥胖与全身性低度炎症和肥胖相关的代谢紊乱有关。考虑到肥胖降低了脾脏中促炎细胞因子的表达，我们评估了白细胞介素（IL）-10（一种由脾脏产生的抗炎细胞因子）在肥胖发病机制中的作用。对脾切除术（SPX）治疗的肥胖野生型和IL-10敲除（IL-10 KO）小鼠全身给予外源性IL-10后，评估了肥胖相关发病机制的变化，包括多个器官的炎症反应。肥胖导致脾脏不能合成细胞因子，包括IL-10，并且肥胖中的促炎细胞因子随后可能从脾脏以外的组织出现，因为IL-10的血清水平而不是促炎细胞因子的血清水平降低，尽管这些细胞因子在高脂肪诱导的肥胖小鼠的脾脏中的表达降低。SPX加重了白色脂肪组织（WAT）和肝脏的炎症反应，并抑制了WAT的肥胖。然而，它加重了肝脏的肥胖。这些SPX诱导的变化被全身给予IL-10抑制。此外，SPX对WAT和IL-10 KO小鼠肝脏中的炎症反应几乎没有影响。这些数据显示了脾来源的IL-10在饮食诱导的变化中的作用，这是WAT和肝脏中的炎症反应的结果。
Obesity is associated with systemic low-grade inflammation and obesity-related metabolic disorders. Considering that obesity decreases the expression of proinflammatory cytokines in the spleen, we assessed the role of interleukin (IL)-10, an anti-inflammatory cytokine produced by the spleen, in the pathogenesis of obesity. Changes in obesity-related pathogenesis, including inflammatory responses in multiple organs, were assessed after systemic administration of exogenous IL-10 to splenectomy (SPX)-treated obese wild-type and IL-10 knockout (IL-10KO) mice. Obesity resulted in the inability of the spleen to synthesize cytokines, including IL-10, and proinflammatory cytokines in obesity are then likely to emerge from tissues other than the spleen because serum levels of IL-10, but not proinflammatory cytokines, decreased despite the expression of these cytokines in the spleen being reduced in high fat–induced obese mice. SPX aggravated the inflammatory response in white adipose tissue (WAT) and the liver and suppressed adiposity in WAT. However, it accentuated adiposity in the liver. These SPX-induced changes were inhibited by systemic administration of IL-10. Moreover, SPX had little effect on the inflammatory responses in WAT and the liver of IL-10KO mice. These data show the role of spleen-derived IL-10 in diet-induced changes as a result of inflammatory responses in WAT and the liver.
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