Adaptive immunity and adipose tissue biology.

Adaptive immunity and adipose tissue biology.
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DOI:
10.1016/j.it.2010.08.001
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发表时间:
2010-10
影响因子:
16.8
通讯作者:
Randall TD
Randall TD
中科院分区:
医学1区
文献类型:
--
作者:
Kaminski DA;Randall TD

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免疫学的研究通常集中在理解造血细胞如何在传统的次级淋巴组织中相互作用。然而,免疫反应及其调节发生在体内的各种环境中。脂肪组织是一种可以影响邻近和嵌入的淋巴细胞并受其影响的环境。尽管这种组织的丰富和广泛分布,尽管肥胖症的流行日益严重,但这些相互作用的研究在过去只得到了很少的重视。在这里,我们回顾了脂肪组织内的淋巴结构的理解,脂肪组织和适应性免疫功能之间的关系,以及这种关系如何有助于肥胖相关疾病的证据。
Studies of immunity typically focus on understanding how hematopoietic cells interact within conventional secondary lymphoid tissues. However, immune reactions and their regulation occur in various environments within the body. Adipose tissue is one context that can influence and be influenced by adjacent and embedded lymphocytes. Despite the abundance and wide distribution of such tissue, and despite a growing obesity epidemic, studies of these interactions have been only marginally appreciated in the past. Here, we review advances in understanding of lymphoid structures within adipose tissue, the relationship between adipose tissue and adaptive immune function, and evidence for how this relationship contributes to obesity-associated diseases.
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