T3DB: a comprehensively annotated database of common toxins and their targets.
T3DB: a comprehensively annotated database of common toxins and their targets.
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DOI：
10.1093/nar/gkp934
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发表时间：
2010-01
影响因子：
14.9
通讯作者：
Wishart DS
中科院分区：
文献类型：
--
作者：
Lim E;Pon A;Djoumbou Y;Knox C;Shrivastava S;Guo AC;Neveu V;Wishart DS
为了获取有关临床相关、常见或重要毒素的有意义的生物学、化学和机制信息，我们开发了毒素和毒素靶标数据库（T3DB）。T3DB是一个独特的生物信息学资源，它将有关常见或普遍存在的毒素及其毒素靶点的全面信息汇编到一个单一的电子库中。该数据库目前包含超过2900种小分子和肽毒素，1300种毒素靶标和超过33000种毒素靶标关联。每个T3DB记录（ToxCard）包含80多个数据字段，提供有关化学特性和描述符、毒性值、蛋白质和基因序列（目标和毒素）、分子和细胞相互作用数据、毒理学数据、机制信息和参考的详细信息。这些信息是从许多来源人工提取和人工核实的，包括其他电子数据库、政府文件、教科书和科学期刊。T3DB的一个关键重点是提供“深度”而不是“广度”，提供详细的描述，作用机制以及关于毒素和毒素目标的信息。T3DB是完全可搜索的，并支持广泛的文本，序列，化学结构和关系查询搜索，类似于人类代谢组数据库（HMDB）和DrugBank。T3DB的潜在应用包括临床代谢组学、毒素靶点预测、毒性预测和毒理学教育。T3DB可在http://www.t3db.org在线获得。
In an effort to capture meaningful biological, chemical and mechanistic information about clinically relevant, commonly encountered or important toxins, we have developed the Toxin and Toxin-Target Database (T3DB). The T3DB is a unique bioinformatics resource that compiles comprehensive information about common or ubiquitous toxins and their toxin-targets into a single electronic repository. The database currently contains over 2900 small molecule and peptide toxins, 1300 toxin-targets and more than 33 000 toxin-target associations. Each T3DB record (ToxCard) contains over 80 data fields providing detailed information on chemical properties and descriptors, toxicity values, protein and gene sequences (for both targets and toxins), molecular and cellular interaction data, toxicological data, mechanistic information and references. This information has been manually extracted and manually verified from numerous sources, including other electronic databases, government documents, textbooks and scientific journals. A key focus of the T3DB is on providing ‘depth’ over ‘breadth’ with detailed descriptions, mechanisms of action, and information on toxins and toxin-targets. T3DB is fully searchable and supports extensive text, sequence, chemical structure and relational query searches, similar to those found in the Human Metabolome Database (HMDB) and DrugBank. Potential applications of the T3DB include clinical metabolomics, toxin target prediction, toxicity prediction and toxicology education. The T3DB is available online at http://www.t3db.org.
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影响因子：
14.9
作者：
Wishart DS;Knox C;Guo AC;Eisner R;Young N;Gautam B;Hau DD;Psychogios N;Dong E;Bouatra S;Mandal R;Sinelnikov I;Xia J;Jia L;Cruz JA;Lim E;Sobsey CA;Shrivastava S;Huang P;Liu P;Fang L;Peng J;Fradette R;Cheng D;Tzur D;Clements M;Lewis A;De Souza A;Zuniga A;Dawe M;Xiong Y;Clive D;Greiner R;Nazyrova A;Shaykhutdinov R;Li L;Vogel HJ;Forsythe I
通讯作者：
Forsythe I
影响因子：
14.9
作者：
Davis AP;Murphy CG;Saraceni-Richards CA;Rosenstein MC;Wiegers TC;Mattingly CJ
通讯作者：
Mattingly CJ
ATDB：动物毒素统一数据库平台
影响因子：
14.9
作者：
He, Quan-Yuan;He, Quan-Ze;Deng, Xing-Can;Yao, Lei;Meng, Er;Liu, Zhong-Hua;Liang, Song-Ping
通讯作者：
Liang, Song-Ping
影响因子：
3.8
作者：
Judson, Richard;Richard, Ann;Wolf, Maritja
通讯作者：
Wolf, Maritja
影响因子：
14.9
作者：
Schmidt U;Struck S;Gruening B;Hossbach J;Jaeger IS;Parol R;Lindequist U;Teuscher E;Preissner R
通讯作者：
Preissner R