Structural modulation of brain development by oxygen: evidence on adolescents migrating from high altitude to sea level environment.
Structural modulation of brain development by oxygen: evidence on adolescents migrating from high altitude to sea level environment.
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氧气对大脑发育的结构调节：青少年从高海拔环境迁移到海平面环境的证据
DOI：
10.1371/journal.pone.0067803
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gong Q
中科院分区：
文献类型：
--
作者：
Zhang J;Zhang H;Chen J;Fan M;Gong Q
本研究旨在探讨发育高峰期高氧对脑结构的调节作用。对21例藏族青少年脑MRI图像进行了基于体素的灰质（GM）和白色（WM）体积的形态计量学分析和基于道的白质各向异性（FA）和平均弥散（MD）的空间统计学分析（15-18岁），出生和成长在青藏高原（2900-4700米），并在过去的4年生活在海平面（SL）。对照组为在高原地区出生和长大的藏族青少年。SL移民在左侧额叶、左侧顶下回和右侧上级顶回的GM体积增加，而在左侧中央前皮质和小脑皮质的多个部位（左侧小叶8、双侧小叶6和双侧小叶1/2）的GM体积减少。SL移民的右侧上级额回WM体积减少。SL移民有较高的FA和较低的MD在多个网站的WM束。此外，我们还发现了通风和循环的变化。小脑第8小叶GM体积与舒张压呈正相关，小脑延髓GM体积与肺活量和低氧反应呈正相关。我们的研究结果表明，高水平的氧气在其发展的高峰期GM的结构调制有关的呼吸和循环的调节，而WM的调制主要表现在髓鞘成熟的增强。
The present study aimed to investigate structural modulation of brain by high level of oxygen during its peak period of development. Voxel-based morphometry analysis of gray matter (GM) and white matter (WM) volumes and Tract-Based Spatial Statistics analysis of WM fractional anisotropy (FA) and mean diffusion (MD) based on MRI images were carried out on 21 Tibetan adolencents (15–18 years), who were born and raised in Qinghai-Tibetan Plateau (2900–4700 m) and have lived at sea level (SL) in the last 4 years. The control group consisted of matched Tibetan adolescents born and raised at high altitude all the time. SL immigrants had increased GM volume in the left insula, left inferior parietal gyrus, and right superior parietal gyrus and decreased GM in the left precentral cortex and multiple sites in cerebellar cortex (left lobule 8, bilateral lobule 6 and crus 1/2). Decreased WM volume was found in the right superior frontal gyrus in SL immigrants. SL immigrants had higher FA and lower MD at multiple sites of WM tracts. Moreover, we detected changes in ventilation and circulation. GM volume in cerebellum lobule 8 positively correlated with diastolic pressure, while GM volume in insula positively correlated vital capacity and hypoxic ventilatory response. Our finding indicate that the structural modulations of GM by high level of oxygen during its peak period of development are related to respiratory and circulatory regulations, while the modulation in WM mainly exhibits an enhancement in myelin maturation.
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影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
2.5
作者：
Gogtay, Nitin;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
影响因子：
7.4
作者：
Bickford, PC;Chadman, K;Joseph, J
通讯作者：
Joseph, J
DOI：
10.1097/00005072-198605000-00006
发表时间：
1986-05-01
影响因子：
3.2
作者：
AHDABBARMADA, M;MOOSSY, J;LIN, MR
通讯作者：
LIN, MR
影响因子：
5.3
作者：
Gerstner, Bettina;DeSilva, Tara M.;Rosenberg, Paul A.
通讯作者：
Rosenberg, Paul A.