Mapping gray matter development: implications for typical development and vulnerability to psychopathology.
Mapping gray matter development: implications for typical development and vulnerability to psychopathology.
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DOI：
10.1016/j.bandc.2009.08.009
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发表时间：
2010-02
影响因子：
2.5
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Gogtay, Nitin;Thompson, Paul M.
最近的脑部磁共振成像（MRI）研究随着时间的推移对大量儿童和青少年进行了反复扫描，随着他们的大脑发育，以非常详细的方式跟踪灰色和白色物质的体积变化。特别关注灰质的变化，在这里，我们解释了早期的研究如何使用特定解剖区域的脑叶体积显示大脑的不同脑叶如何以不同的速度成熟。随着更复杂的大脑映射方法的出现，使用详细的3D和4D（动态）模型绘制皮层成熟的动态轨迹已经成为可能，显示了通过皮层演变的变化波。这导致了各种各样的延时电影，揭示了精神分裂症、双相情感障碍，甚至是有遗传风险的兄弟姐妹与正常发育的特征偏差。我们描述了这些方法是如何帮助澄清皮质发育与认知能力、功能恢复或疾病下降以及正在进行的髓鞘形成过程之间的关系的。这些延时图也被用于研究基因型和药物对皮质成熟的影响，为研究影响大脑发育的因素提供了一个强大的框架。
Recent studies with brain magnetic resonance imaging (MRI) have scanned large numbers of children and adolescents repeatedly over time, as their brains develop, tracking volumetric changes in gray and white matter in remarkable detail. Focusing on gray matter changes specifically, here we explain how earlier studies using lobar volumes of specific anatomical regions showed how different lobes of the brain matured at different rates. With the advent of more sophisticated brain mapping methods, it has become possible to chart the dynamic trajectory of cortical maturation using detailed 3D and 4D (dynamic) models, showing spreading waves of changes evolving through the cortex. This led to a variety of time-lapse films revealing characteristic deviations from normal development in schizophrenia, bipolar illness, and even in siblings at genetic risk for these disorders. We describe how these methods have helped clarify how cortical development relates to cognitive performance, functional recovery or decline in illness, and ongoing myelination processes. These time-lapse maps have also been used to study effects of genotype and medication on cortical maturation, presenting a powerful framework to study factors that influence the developing brain.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
10.6
作者：
Bartzokis, G;Nuechterlein, KH;Mintz, J
通讯作者：
Mintz, J
影响因子：
--
作者：
Gogtay, Nitin;Greenstein, Deanna;Rapoport, Judith
通讯作者：
Rapoport, Judith
影响因子：
--
作者：
Cannon, TD;Hennah, W;Peltonen, L
通讯作者：
Peltonen, L
影响因子：
--
作者：
Asarnow, RF;Nuechterlein, KH;Kendler, KS
通讯作者：
Kendler, KS