Modelling from the experimental developmental biologists viewpoint.

Modelling from the experimental developmental biologists viewpoint.
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DOI:
10.1016/j.semcdb.2014.07.006
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发表时间:
2014-11
影响因子:
7.3
通讯作者:
Green, Jeremy B. A.
Green, Jeremy B. A.
中科院分区:
生物学2区
文献类型:
--
作者:
Economou, Andrew D.;Green, Jeremy B. A.

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在这篇综述中,我们认为反应扩散的原型模型在发育生物学。我们认为它的历史与实验工作,因为它是在1952年首次提出的图灵和恢复在20世纪70年代的迈因哈特。然后,我们讨论了最新的例子,解决这个模型的实验,包括在捕捉物理化学表现的模型机制在一个真实的发展系统仍然存在的挑战。最后,我们讨论了该模型的现状和使用的实验社区。
In this review we consider Reaction–Diffusion as the archetype of a model in developmental biology. We consider its history in relation to experimental work since it was first proposed in 1952 by Turing and revived in the 1970s by Meinhardt. We then discuss the most recent examples of experiments that address this model, including the challenges that remain in capturing the physico-chemical manifestation of the model mechanism in a real developmental system. Finally we discuss the model's current status and use in the experimental community.
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