A meta-analytic study of experimental and chronic orofacial pain excluding headache disorders.
A meta-analytic study of experimental and chronic orofacial pain excluding headache disorders.
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DOI：
10.1016/j.nicl.2018.09.018
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Moayedi M
中科院分区：
文献类型：
--
作者：
Ayoub LJ;Seminowicz DA;Moayedi M
慢性口面部疼痛(COFP)是一种普遍存在的疾病，会影响到头部、颈部和面部。神经成像研究报告了功能和灰质异常，但并不是所有的研究都报告了一致的结果。识别COFP之间的收敛异常为未来旨在阐明常见中枢神经系统机制的假说驱动的研究提供了基础。在这里，我们根据Prisma指南进行了三个基于坐标的荟萃分析，以阐明口腔面部疼痛障碍的中心机制。具体地说，我们调查了以下一致的模式：(1)健康受试者对实验性口面部疼痛的脑功能，(2)COFP患者的结构和(3)脑功能异常。我们使用GingerALE计算了基于坐标的Meta分析。实验性疼痛Meta分析显示，双侧丘脑、扣带回后皮质和次级躯体感觉皮质、右侧顶叶后皮质延伸至右侧初级躯体感觉皮质口面部和右侧脑岛的脑活动增加，右侧躯体运动区的活动减少。结构COFP荟萃分析发现，与健康对照组相比，COFP患者右侧腹侧丘脑和后壳核中的灰质体积/浓度持续较高。功能性COFP荟萃分析发现，与健康对照组相比，COFP患者左侧丘脑内侧和后部的脑活动持续增加，而左侧后脑岛的活动减少。总体而言，这些发现提供了跨不同COFP障碍的与疼痛相关的区域，即丘脑和脑岛的大脑异常的证据。丘脑结构和功能异常的汇聚表明这一区域在COFP病理生理学中起着关键作用。识别COFP中的汇聚性异常可以阐明新的治疗靶点。实验性口面部疼痛与伤害性信息处理脑区的活动有关。慢性口面部疼痛(COFP)与丘脑活动和灰质异常有关。我们的综述强调了更多高质量COFP脑成像研究的必要性。
Chronic orofacial pain (COFP) disorders are prevalent and debilitating pain conditions affecting the head, neck and face areas. Neuroimaging studies have reported functional and grey matter abnormalities, but not all the studies have reported consistent findings. Identifying convergent abnormalities across COFPs provides a basis for future hypothesis-driven research aimed at elucidating common CNS mechanisms. Here, we perform three coordinate-based meta-analyses according to PRISMA guidelines to elucidate the central mechanisms of orofacial pain disorders. Specifically, we investigated consistent patterns of: (1) brain function to experimental orofacial pain in healthy subjects, (2) structural and (3) functional brain abnormalities in COFP. We computed our coordinate-based meta-analyses using GingerALE. The experimental pain meta-analysis revealed increased brain activity in bilateral thalami, posterior mid-cingulate cortices, and secondary somatosensory cortices, the right posterior parietal cortex extending to the orofacial region of the right primary somatosensory cortex and the right insula, and decreased activity in the right somatomotor regions. The structural COFP meta-analysis identified consistent higher grey matter volume/concentration in the right ventral thalamus and posterior putamen of COFP patients compared to healthy controls. The functional COFP meta-analysis identified a consistent increase in brain activity in the left medial and posterior thalamus and lesser activity in the left posterior insula in COFP, compared to healthy controls. Overall, these findings provide evidence of brain abnormalities in pain-related regions, namely the thalamus and insula, across different COFP disorders. The convergence of thalamic abnormalities in both structure and function suggest a key role for this region in COFP pathophysiology. Identifying convergent abnormalities in COFP can elucidate novel therapeutic targets. Experimental orofacial pain is associated with activity in nociceptive processing brain areas. Chronic orofacial pain (COFP) is associated with abnormal thalamic activity and grey matter. Our review highlights the need for more high quality COFP brain imaging studies.
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影响因子：
4.8
作者：
Eickhoff, Simon B.;Laird, Angela R.;Grefkes, Christian;Wang, Ling E.;Zilles, Karl;Fox, Peter T.
通讯作者：
Fox, Peter T.
DOI：
10.1073/pnas.1605044113
发表时间：
2016-08-30
影响因子：
11.1
作者：
Dum, Richard P.;Levinthal, David J.;Strick, Peter L.
通讯作者：
Strick, Peter L.
影响因子：
6.3
作者：
Downs, SH;Black, N
通讯作者：
Black, N
影响因子：
2.7
作者：
Bogdanov VB;Viganò A;Noirhomme Q;Bogdanova OV;Guy N;Laureys S;Renshaw PF;Dallel R;Phillips C;Schoenen J
通讯作者：
Schoenen J
DOI：
10.1016/j.tripleo.2005.12.018
发表时间：
2006-12-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
de Leeuw, Reny;Davis, C. Ervin;Andersen, Anders H.
通讯作者：
Andersen, Anders H.