Cerebral responses and role of the prefrontal cortex in conditioned pain modulation: an fMRI study in healthy subjects.
Cerebral responses and role of the prefrontal cortex in conditioned pain modulation: an fMRI study in healthy subjects.
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DOI：
10.1016/j.bbr.2014.11.028
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发表时间：
2015-03-15
影响因子：
2.7
通讯作者：
Schoenen J
中科院分区：
文献类型：
--
作者：
Bogdanov VB;Viganò A;Noirhomme Q;Bogdanova OV;Guy N;Laureys S;Renshaw PF;Dallel R;Phillips C;Schoenen J
条件性疼痛调制（CPM）的机制是多方面的。我们寻找在多试验异位有害冷条件反射过程中前额叶皮层活动的个体差异与对阶段性热痛的大脑反应调制之间的联系。在24名健康女性受试者中，我们通过对右脚交替施加冰冷或不冷不热的敷布来调节对左手的激光热刺激。我们比较了疼痛等级与大脑功能磁共振成像BOLD反应。我们还分析了CPM和由异位冷条件反射本身产生的BOLD变化之间的关系，以及焦虑和习惯化对冷痛评分的影响。在冷应用的早期和持续阶段，分别在楔前叶和左后叶/SII中确定了特定的脑激活。在冷处理期间，激光疼痛减少（n = 7）、增加（n = 10）或保持不变（n = 7）。在个体水平上，心理物理效应与左后颞叶/SII中激光诱导BOLD反应的冷诱导调制成正比。后者与BOLD反应记录80秒前在前扣带回，眶额和外侧前额叶皮质的冷应用程序的初始10秒阶段。在异位冷刺激期间，高度焦虑和习惯冷痛与更大的激光热诱导疼痛相关。习惯化也与早期冷诱导的眶额反应有关。我们的结论是，条件性疼痛调制的个体差异与不同水平的前额叶皮层激活的早期部分的条件刺激，可能是由于不同水平的特质焦虑。
The mechanisms underlying conditioned pain modulation (CPM) are multifaceted. We searched for a link between individual differences in prefrontal cortex activity during multi-trial heterotopic noxious cold conditioning and modulation of the cerebral response to phasic heat pain. In 24 healthy female subjects, we conditioned laser heat stimuli to the left hand by applying alternatively ice-cold or lukewarm compresses to the right foot. We compared pain ratings with cerebral fMRI BOLD responses. We also analyzed the relation between CPM and BOLD changes produced by the heterotopic cold conditioning itself, as well as the impact of anxiety and habituation of cold-pain ratings. Specific cerebral activation was identified in precuneus and left posterior insula/SII, respectively, during early and sustained phases of cold application. During cold conditioning, laser pain decreased (n = 7), increased (n = 10) or stayed unchanged (n = 7). At the individual level, the psychophysical effect was directly proportional to the cold-induced modulation of the laser-induced BOLD response in left posterior insula/SII. The latter correlated with the BOLD response recorded 80 s earlier during the initial 10-s phase of cold application in anterior cingulate, orbitofrontal and lateral prefrontal cortices. High anxiety and habituation of cold pain were associated with greater laser heat-induced pain during heterotopic cold stimulation. The habituation was also linked to the early cold-induced orbitofrontal responses. We conclude that individual differences in conditioned pain modulation are related to different levels of prefrontal cortical activation by the early part of the conditioning stimulus, possibly due to different levels in trait anxiety.
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影响因子：
7.4
作者：
Goffaux, Philippe;Redmond, William John;Marchand, Serge
通讯作者：
Marchand, Serge
影响因子：
7.4
作者：
Kong J;Jensen K;Loiotile R;Cheetham A;Wey HY;Tan Y;Rosen B;Smoller JW;Kaptchuk TJ;Gollub RL
通讯作者：
Gollub RL
影响因子：
2.9
作者：
MAYER, DJ;LIEBESKIND, JC
通讯作者：
LIEBESKIND, JC
影响因子：
3.3
作者：
Harper, RM;Macey, PM;Yan-Go, FL
通讯作者：
Yan-Go, FL
影响因子：
7.4
作者：
de Tommaso, Marina;Difruscolo, Olimpia;Livrea, Paolo
通讯作者：
Livrea, Paolo