Histological validation of prostate tissue composition measurement using hybrid multi-dimensional MRI: agreement with pathologists' measures.
Histological validation of prostate tissue composition measurement using hybrid multi-dimensional MRI: agreement with pathologists' measures.
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DOI：
10.1007/s00261-021-03371-7
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Oto A
中科院分区：
文献类型：
--
作者：
Chatterjee A;Antic T;Gallan AJ;Paner GP;Lin LI;Karczmar GS;Oto A
通过与病理学家在全前列腺切除术后对临床组织病理学切片的解释的参考标准（地面实况）结果进行比较，验证使用混合多维MRI（HM-MRI）测量的前列腺组织成分。36例活检证实的前列腺癌前瞻性参与者在根治性前列腺切除术前接受了3 T MRI。使用回波时间为57、70、150、200 ms和b值为0、150、750、1500 s/mm 2的所有组合采集轴向HM-MRI，并使用定制软件使用三室信号模型拟合数据，以生成每个组织成分（基质、上皮、管腔）的体积。三位经验丰富的泌尿生殖病理学家独立地以及一致地审查了每一个组织学图像，并提供了对应于MRI的感兴趣区域的上皮和管腔百分比的估计值（n = 165; 64例前列腺癌和101例良性组织）。使用总偏差指数（TDI 0.9）对使用HM-MRI测量的组织组成和病理学家共识的参考标准结果进行一致性统计。基于初步结果显示病理学家TDI 0.9 = 25%的典型变异，我们确定，如果TDI 0.9的95%单侧置信上限小于30%，则我们将宣布一致性可接受。HM-MRI的组织成分测量结果与3位病理学家一致同意的地面实况结果相比，显示在测量上皮和管腔时，90%的绝对配对差异（TDI 0.9）分别在18.8%和22.4%范围内。我们有95%的置信度，90%的绝对配对差异分别在上皮和管腔测量的20.6%和24.2%范围内。这低于我们的标准30%和病理学家之间的一致性（上皮为22.3%，管腔为24.2%），因此我们接受HM-MRI的一致性性能。结果显示，基于上皮（HM-MRI：0.87，病理学家：0.97）和管腔体积（HM-MRI：0.85，病理学家：0.77）区分癌症与良性组织的ROC曲线下面积极佳。使用混合多维MRI和病理学家共识进行组织成分测量的一致性与评估者（病理学家）之间的一致性相同。
To validate prostate tissue composition measured using hybrid multi-dimensional MRI (HM-MRI) by comparing with reference standard (ground truth) results from pathologists’ interpretation of clinical histopathology slides following whole mount prostatectomy. 36 prospective participants with biopsy-confirmed prostate cancer underwent 3 T MRI prior to radical prostatectomy. Axial HM-MRI was acquired with all combinations of echo times of 57, 70, 150, 200 ms and b-values of 0, 150, 750, 1500 s/mm2 and data were fitted using a 3-compartment signal model using custom software to generate volumes for each tissue component (stroma, epithelium, lumen). Three experienced genitourinary pathologists independently as well as in consensus reviewed each histology image and provide an estimate of percentage of epithelium and lumen for regions-of-interest corresponding to MRI (n = 165; 64 prostate cancers and 101 benign tissue). Agreement statistics using total deviation index (TDI0.9) was performed for tissue composition measured using HM-MRI and reference standard results from pathologists’ consensus. Based on the initial results showing typical variation among pathologists TDI0.9 = 25%, we determined we will declare acceptable agreement if the 95% one-sided upper confident limit of TDI0.9 is less than 30%. The results of tissue composition measurement from HM-MRI compared to ground truth results from the consensus of 3 pathologists, reveal that ninety percent of absolute paired differences (TDI0.9) were within 18.8% and 22.4% in measuring epithelium and lumen, respectively. We are 95% confident that 90% of absolute paired differences were within 20.6% and 24.2% in measuring epithelium and lumen, respectively. These were less than our criterion of 30% and inter-pathologists’ agreement (22.3% for epithelium and 24.2% for lumen) and therefore we accept the agreement performance of HM-MRI. The results revealed excellent area under the ROC curve for differentiating cancer from benign tissue based on epithelium (HM-MRI: 0.87, pathologists: 0.97) and lumen volume (HM-MRI: 0.85, pathologists: 0.77). The agreement in tissue composition measurement using hybrid multidimensional MRI and consensus of pathologists is on par with the inter-raters (pathologists) agreement.
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DOI：
10.1007/978-1-4614-0562-7
发表时间：
2012-01-01
期刊：
STATISTICAL TOOLS FOR MEASURING AGREEMENT
影响因子：
--
作者：
Lin, Lawrence;Hedayat, A. S.;Wu, Wenting
通讯作者：
Wu, Wenting
影响因子：
2.4
作者：
Chatterjee, Aritrick;Gallan, Alexander J.;Oto, Aytekin
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影响因子：
2.4
作者：
Bajgiran, Amirhossein Mohammadian;Mirak, Sohrab Afshari;Raman, Steven S.
通讯作者：
Raman, Steven S.
影响因子：
2.4
作者：
Chatterjee, Aritrick;Harmath, Carla;Oto, Aytekin
通讯作者：
Oto, Aytekin
影响因子：
2.4
作者：
Chatterjee, Aritrick;Thomas, Stephen;Oto, Aytekin
通讯作者：
Oto, Aytekin