Associations Between Smoking and Primary Sjögren Syndrome Classification Using the Sjögren's International Collaborative Clinical Alliance Cohort.
Associations Between Smoking and Primary Sjögren Syndrome Classification Using the Sjögren's International Collaborative Clinical Alliance Cohort.
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DOI：
10.1002/acr2.11362
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发表时间：
2022-03
影响因子：
3.4
通讯作者：
Gonzales JA
中科院分区：
文献类型：
--
作者：
Gebreegziabher EA;Oldenburg CE;Shiboski SC;Baer AN;Jordan RC;Rose-Nussbaumer JR;Bunya VY;Akpek EK;Criswell LA;Shiboski CH;Lietman TM;Gonzales JA
本研究的目的是探讨吸烟与原发性干燥综合征 (pSS) 分类和 pSS 诊断测试结果的关系。我们假设，与不吸烟者相比，过去和现在的吸烟者被归类为干燥综合征 (SS) 的几率较低，并且个体 SS 诊断测试结果异常的几率较低。怀疑或确诊患有 pSS 的参与者被纳入干燥国际合作临床联盟 (SICCA) 登记处，并进行口腔、眼部和风湿病检查；采集血液和唾液样本；以及进行唇唾液腺活检检查；他们还完成了基线调查问卷。使用逻辑回归来确定吸烟状况是否与 pSS 分类和个体 pSS 诊断测试结果相关。 SICCA 共有 3514 名参与者注册。共有 1541 例 (52.9%) 符合 pSS 分类标准。与从不吸烟者相比，当前吸烟者被归类为 pSS 的几率降低，焦点评分 ≥ 1 和抗 SSA/抗 SSB 抗体血清学阳性的几率降低，出现干眼病异常体征或检测结果的几率也降低。与从不吸烟者相比，过去吸烟者被归类为患有 pSS 以及个体 pSS 诊断测试结果异常的几率并没有统计学上显着降低。与从不吸烟者相比，SICCA 队列中当前吸烟者被归类为 pSS 的几率较低，表现出干眼病异常体征和测试结果的几率较低，并且进行支持 pSS 分类的唇唾液腺活检的几率较低。然而，这种负相关并不表明当前吸烟对 pSS 有任何益处。
The objective of this study was to examine the association of smoking with Primary Sjögren syndrome (pSS) classification and pSS diagnostic test results. We hypothesized that past and current smokers would have lower odds of being classified as having Sjögren syndrome (SS) and lower odds of having abnormal individual SS diagnostic test results compared with nonsmokers. Participants with suspected or established pSS were enrolled into the Sjögren's International Collaborative Clinical Alliance (SICCA) registry and had oral, ocular, and rheumatologic examinations performed; blood and saliva samples collected; and labial salivary gland biopsy examinations performed; they also completed questionnaires at baseline. Logistic regression was used to determine whether smoking status was associated with pSS classification and individual pSS diagnostic test results. A total of 3514 participants were enrolled in SICCA. A total of 1541 (52.9%) met classification criteria for pSS. Compared with never smokers, current smokers had reduced odds of being classified as having pSS, reduced odds of having a focus score ≥ 1 and serologic positivity for anti‐SSA/anti‐SSB antibodies, and lower odds of having abnormal signs or test results of dry eye disease. Compared with never smokers, past smokers did not have a statistically significant reduction in odds of being classified as having pSS and of having abnormal individual pSS diagnostic test results. Compared with never smokers, current smokers in the SICCA cohort had lower odds of being classified as having pSS, lower odds of exhibiting abnormal signs and test results for dry eye disease, and lower odds of having a labial salivary gland biopsy supportive of pSS classification. Such negative associations, however, do not suggest that current smoking is of any benefit with respect to pSS.
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