A prospective study of cigarette smoking and the risk of inflammatory bowel disease in women.
A prospective study of cigarette smoking and the risk of inflammatory bowel disease in women.
复制标题
DOI：
10.1038/ajg.2012.196
复制
发表时间：
2012-09
影响因子：
9.8
通讯作者：
Fuchs, Charles S.
中科院分区：
文献类型：
--
作者：
Higuchi, Leslie M.;Khalili, Hamed;Chan, Andrew T.;Richter, James M.;Bousvaros, Athos;Fuchs, Charles S.
吸烟，特别是戒烟对克罗恩病（CD）和溃疡性结肠炎（UC）风险影响的长期数据有限。我们在护士健康研究（NHS）和护士健康研究II（NHS II）中对229，111名女性进行了前瞻性研究。我们每两年收集一次关于吸烟、其他风险因素和经病历审查确认的CD或UC诊断的最新数据。在NHS的32年和NHS II的18年中，我们记录了336例CD事件病例和400例UC事件病例。与从不吸烟者相比，CD的多变量风险比（HR）在当前吸烟者中为1.90（95%置信区间[CI]，1.42-2.53），在既往吸烟者中为1.35（95% CI，1.05-1.73）。增加吸烟包年数与CD风险增加相关（P趋势< 0.0001），而戒烟与风险降低相关。相比之下，当前吸烟者中UC的多变量HR为0.86（95% CI，0.61-1.20），既往吸烟者中为1.56（95% CI，1.26-1.93）。UC的风险在戒烟后2 - 5年内显著增加（HR，3.06; 95% CI，2.00-4.67），并在20年内持续升高。目前吸烟与CD风险增加相关，但与UC无关。相比之下，既往吸烟与UC风险增加相关，风险在戒烟后持续20年以上。
Long-term data on the influence of cigarette smoking, especially cessation, on the risk of Crohn’s disease (CD) and ulcerative colitis (UC) are limited. We conducted a prospective study of 229,111 women in the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHS II). Biennially, we collected updated data on cigarette smoking, other risk factors, and diagnoses of CD or UC confirmed by medical record review. Over 32 years in NHS and 18 years in NHS II, we documented 336 incident cases of CD and 400 incident cases of UC. Compared to never smokers, the multivariate hazard ratio (HR) of CD was 1.90 (95% confidence interval [CI], 1.42–2.53) among current smokers and 1.35 (95% CI, 1.05–1.73) among former smokers. Increasing pack-years was associated with increasing risk of CD (Ptrend< 0.0001) whereas smoking cessation was associated with an attenuation of risk. In contrast, the multivariate HRs of UC was 0.86 (95% CI, 0.61–1.20) among current smokers and 1.56 (95% CI, 1.26–1.93) among former smokers. The risk of UC was significantly increased within 2 to 5 years of smoking cessation (HR, 3.06; 95% CI, 2.00–4.67) and remained persistently elevated over 20 years. Current smoking is associated with an increased risk of CD, but not UC. In contrast, former smoking is associated with an increased risk of UC, with risk persisting over two decades after cessation.
登录
查看更多内容
影响因子：
1.9
作者：
Fonager, K;Sorensen, HT;Vyberg, M
通讯作者：
Vyberg, M
影响因子：
158.5
作者：
Hu, FB;Manson, JE;Willett, WC
通讯作者：
Willett, WC
影响因子：
24.5
作者：
Bridger, S;Lee, JCW;Macpherson, AJ
通讯作者：
Macpherson, AJ
影响因子：
24.5
作者：
LINDBERG, E;TYSK, C;JARNEROT, G
通讯作者：
JARNEROT, G
影响因子：
105.7
作者：
LOGAN, RFA;EDMOND, M;LANGMAN, MJS
通讯作者：
LANGMAN, MJS