The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women.
The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women.
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双酚 A (BPA) 暴露对脂肪量和血清瘦素浓度的影响对非肥胖绝经前女性的骨矿物质密度没有影响。
DOI：
10.1016/j.clinbiochem.2012.08.024
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
刘建民
中科院分区：
文献类型：
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作者：
刘建民
双酚A（BPA）暴露可能会促进肥胖，但其对骨密度（BMD）的影响尚未在人类中报道。我们的目的是研究BPA暴露，身体成分，血清雌二醇，瘦素，骨钙素水平和骨密度之间的关系在健康的绝经前women.DESIGN AND METHODS在这个横断面研究中，共有246名健康的绝经前妇女年龄在20岁及以上，定期月经周期进行了调查。用DXA测量体重指数（BMI）、脂肪量、去脂肪量和骨密度。血清雌二醇、瘦素、骨钙素、尿BPA和NTx水平也进行了检测。在校正年龄和BMI后，尿BPA水平与脂肪质量（r=0.193，p=0.006）和瘦素（r=0.236，p=0.001）呈正相关，但与去脂肪质量无关。BPA与血清雌二醇水平、骨密度、骨吸收标志物NTx和骨形成参数骨钙素也不相关。多元逐步回归分析证实，血清瘦素水平受脂肪质量（β=0.746，p<0.001）和BPA（β=0.127，p=0.01）的正相关影响，但与去脂肪质量（β=-0.196，p<0.001）呈负相关。然而，腰椎骨密度的变化（β=0.298，p<0.001）和股骨颈（β=0.305，p<0.001）主要由去脂体重解释，而与脂肪量、瘦素和BPA暴露无关。结论BPA暴露虽然与脂肪量增加和血清瘦素水平升高有关，但对绝经前妇女BMD的影响是中性的。这可能是由于无脂肪质量的唯一作用，这与确定BMD的BPA无关。
OBJECTIVESBisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. We aimed to examine the relationships between BPA exposure, body composition, serum estradiol, leptin, osteocalcin levels and BMDs in healthy premenopausal women.DESIGN AND METHODSIn this cross-sectional study, a total of 246 healthy premenopausal women aged 20years and older with regular menstrual cycles were investigated. Body mass index (BMI), fat mass, fat-free mass and BMDs were measured by DXA. Serum estradiol, leptin, osteocalcin, urinary BPA and NTx levels were also tested.RESULTSUrinary BPA levels were positively associated with fat mass (r=0.193, p=0.006) and leptin (r=0.236, p=0.001) but not with fat-free mass after adjusting for age and BMI. BPA was not associated with serum estradiol levels, BMDs, or bone resorption marker NTx and bone formation parameter osteocalcin, either. A multivariate stepwise regression analysis confirmed that serum leptin levels were positively influenced by fat mass (β=0.746, p<0.001) and BPA (β=0.127, p=0.01) but negatively correlated with fat-free mass (β=−0.196, p<0.001). However, the changes of BMDs at the lumbar spine (β=0.298, p<0.001) and femoral neck (β=0.305, p<0.001) were primarily explained by fat-free mass, and were irrelevant of the fat mass, leptin or BPA exposure.CONCLUSIONSAlthough BPA exposure is related with increased amount of fat mass and elevated serum leptin levels, it has neutral effect on BMDs in premenopausal women, possibly due to the exclusive role of fat-free mass, which is unrelated to BPA in determining BMDs.
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影响因子：
10.4
作者：
Alonso-Magdalena P;Vieira E;Soriano S;Menes L;Burks D;Quesada I;Nadal A
通讯作者：
Nadal A
男性和女性泌尿双酚A浓度的时间变异性和预测因子。
影响因子：
10.4
作者：
Mahalingaiah, Shruthi;Meeker, John D.;Pearson, Kimberly R.;Calafat, Antonia M.;Ye, Xiaoyun;Petrozza, John;Hauser, Russ
通讯作者：
Hauser, Russ
DOI：
10.1046/j.1432-1033.2002.02879.x
发表时间：
2002-04
期刊：
European journal of biochemistry
影响因子：
--
作者：
K. Toda;C. Miyaura;Teruhiko Okada;Y. Shizuta
通讯作者：
K. Toda;C. Miyaura;Teruhiko Okada;Y. Shizuta
影响因子：
4.1
作者：
Rubin BS;Soto AM
通讯作者：
Soto AM
影响因子：
18.2
作者：
通讯作者：
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