Temporal variability and predictors of urinary bisphenol A concentrations in men and women.
Temporal variability and predictors of urinary bisphenol A concentrations in men and women.
复制标题
男性和女性泌尿双酚A浓度的时间变异性和预测因子。
DOI：
10.1289/ehp.10605
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发表时间：
2008-02
影响因子：
10.4
通讯作者：
Hauser, Russ
中科院分区：
文献类型：
--
作者：
Mahalingaiah, Shruthi;Meeker, John D.;Pearson, Kimberly R.;Calafat, Antonia M.;Ye, Xiaoyun;Petrozza, John;Hauser, Russ
双酚A（BPA）用于制造聚合物材料，如聚碳酸酯塑料，并存在于各种消费品中。最近的数据显示，BPA在美国人口中广泛存在。本研究的目的是确定BPA暴露的时间变异性和预测因子。我们测量了来自马萨诸塞州综合医院生育中心的男性和女性患者的尿BPA浓度。在2004年至2006年期间，从82名受试者中收集了217份尿液样本：45名女性（145份样本）和37名男性（72份样本）。其中，24名女性和男性是伴侣，并在同一天提供了42对样本。10名妇女在随访期间怀孕。在217个尿液样本中，BPA浓度中位数为1.20微克/升，范围从低于检测限（0.4微克/升）至42.6微克/升。年龄、体重指数和性别不是尿BPA浓度的显著预测因子。孕妇尿BPA浓度比未孕妇女高26%（-26%，115%）（p > 0.05）。同一天女性和男性伴侣的尿BPA浓度相关（r = 0.36; p = 0.02）。使用单个尿液样本将受试者分类为最高三分位数的灵敏度为0.64。我们发现，与同一妇女的非妊娠样本相比，妊娠妇女的尿BPA浓度无显着增加。在同一天从伴侣那里采集的样本是相关的，这表明他们有共同的接触源。最后，一个单一的尿液样本显示中等灵敏度预测一个主题的三分位分类。
Bisphenol A (BPA) is used to manufacture polymeric materials, such as polycarbonate plastics, and is found in a variety of consumer products. Recent data show widespread BPA exposure among the U.S. population. Our goal in the present study was to determine the temporal variability and predictors of BPA exposure. We measured urinary concentrations of BPA among male and female patients from the Massachusetts General Hospital Fertility Center. Between 2004 and 2006, 217 urine samples were collected from 82 subjects: 45 women (145 samples) and 37 men (72 samples). Of these, 24 women and men were partners and contributed 42 pairs of samples collected on the same day. Ten women became pregnant during the follow-up period. Among the 217 urine samples, the median BPA concentration was 1.20 μg/L, ranging from below the limit of detection (0.4 μg/L) to 42.6 μg/L. Age, body mass index, and sex were not significant predictors of urinary BPA concentrations. BPA urinary concentrations among pregnant women were 26% higher (–26%, +115%) than those among the same women when not pregnant (p > 0.05). The urinary BPA concentrations of the female and male partner on the same day were correlated (r = 0.36; p = 0.02). The sensitivity of classifying a subject in the highest tertile using a single urine sample was 0.64. We found a nonsignificant increase in urinary BPA concentrations in women while pregnant compared with nonpregnant samples from the same women. Samples collected from partners on the same day were correlated, suggesting shared sources of exposure. Finally, a single urine sample showed moderate sensitivity for predicting a subject’s tertile categorization.
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影响因子：
4.7
作者：
Arakawa, Chikako;Fujimaki, Kayumi;Shiraishi, Hiroaki
通讯作者：
Shiraishi, Hiroaki
DOI：
10.1016/j.bbrc.2003.10.135
发表时间：
2003-12-12
影响因子：
3.1
作者：
Kim, YH;Kim, CS;Yang, MH
通讯作者：
Yang, MH
影响因子：
10.4
作者：
Calafat AM;Kuklenyik Z;Reidy JA;Caudill SP;Ekong J;Needham LL
通讯作者：
Needham LL
DOI：
10.1038/137996a0
发表时间：
1936-01-01
期刊：
NATURE [LONDON]
影响因子：
--
作者：
DODDS, E. C;LAWSON, WILFRED
通讯作者：
LAWSON, WILFRED
DOI：
10.1007/s10856-005-0627-8
发表时间：
2005-04-01
影响因子：
3.7
作者：
Sasaki, N;Okuda, K;Kubono, K
通讯作者：
Kubono, K