Unique prediction of developmental psychopathology from genetic and familial risk.
Unique prediction of developmental psychopathology from genetic and familial risk.
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DOI：
10.1111/jcpp.13649
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发表时间：
2022-12
影响因子：
7.6
通讯作者：
Fan, Chun Chieh
中科院分区：
文献类型：
--
作者：
Loughnan, Robert J.;Palmer, Clare E.;Makowski, Carolina;Thompson, Wesley K.;Barch, Deanna M.;Jernigan, Terry L.;Dale, Anders M.;Fan, Chun Chieh
早期发现对于减轻精神疾病日益加重的负担至关重要。然而，精神病理学测量和遗传预测的特异性在青年中尚不清楚。我们测量了精神病理学遗传风险（多基因风险评分（PRS）和家族史（FH）措施）和广泛的行为措施之间的关联，在一个大样本（n=5204）的早期青少年参与者（9-11岁）从青少年大脑和认知发展研究SM。相关性的测量包括考虑和不考虑遗传风险测量的共享方差。当控制其他精神疾病的遗传风险时，有问题的阿片类药物使用（POU）的多基因风险与较低的行为抑制唯一相关。注意缺陷多动障碍（ADHD）、抑郁症（DEP）和自杀未遂（SUIC）的PRS与外化、内化和精神病相关行为有许多显著的关联。然而，当考虑到遗传和家族风险的所有措施时，这些PRS也显示出明确的，独特的关联模式。ASD、BIP、SCZ和自杀未遂的多基因风险可唯一预测认知能力的变异性。FH解释了PRS以上和之外行为的独特变异性，反之亦然，与PRS相比，FH测量解释了更大比例的独特变异性。我们的研究结果表明，在年轻人中，许多行为表现出共同的遗传影响;然而，对于特定疾病遗传风险高的个体，新兴精神病理学的特征也具有特异性。这可能是有用的量化发展中的精神病理学的早期，差异风险。
Early detection is critical for easing the rising burden of psychiatric disorders. However, the specificity of psychopathological measurements and genetic predictors is unclear among youth. We measured associations between genetic risk for psychopathology (polygenic risk scores (PRS) and family history (FH) measures) and a wide range of behavioral measures in a large sample (n=5204) of early adolescent participants (9–11 years) from the Adolescent Brain and Cognitive Development StudySM. Associations were measured both with and without accounting for shared variance across measures of genetic risk. When controlling for genetic risk for other psychiatric disorders, polygenic risk for problematic opioid use (POU) uniquely associated with lower behavioral inhibition. Attention Deficit Hyperactivity Disorder (ADHD), depression (DEP) and attempted suicide (SUIC) PRS shared many significant associations with externalizing, internalizing and psychosis-related behaviors. However, when accounting for all measures of genetic and familial risk these PRS also showed clear, unique patterns of association. Polygenic risk for ASD, BIP, SCZ and attempted suicide uniquely predicted variability in cognitive performance. FH accounted for unique variability in behavior above and beyond PRS and vice versa, with FH measures explaining a greater proportion of unique variability compared to the PRS. Our results indicate that, among youth, many behaviors show shared genetic influences; however, there is also specificity in the profile of emerging psychopathologies for individuals with high genetic risk for particular disorders. This may be useful for quantifying early, differential risk for psychopathology in development.
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影响因子：
7.8
作者：
Dalsgaard, S.;Mortensen, P. B.;Thomsen, P. H.
通讯作者：
Thomsen, P. H.
影响因子：
25.8
作者：
Karcher, Nicole R.;Barch, Deanna M.;Loewy, Rachel L.
通讯作者：
Loewy, Rachel L.
影响因子：
6.6
作者：
Ising, Helga K.;Veling, Wim;van der Gaag, Mark
通讯作者：
van der Gaag, Mark
影响因子：
25.8
作者：
Agerbo, Esben;Trabjerg, Betina B.;Musliner, Katherine L.
通讯作者：
Musliner, Katherine L.
影响因子：
16.6
作者：
Davies G;Lam M;Harris SE;Trampush JW;Luciano M;Hill WD;Hagenaars SP;Ritchie SJ;Marioni RE;Fawns-Ritchie C;Liewald DCM;Okely JA;Ahola-Olli AV;Barnes CLK;Bertram L;Bis JC;Burdick KE;Christoforou A;DeRosse P;Djurovic S;Espeseth T;Giakoumaki S;Giddaluru S;Gustavson DE;Hayward C;Hofer E;Ikram MA;Karlsson R;Knowles E;Lahti J;Leber M;Li S;Mather KA;Melle I;Morris D;Oldmeadow C;Palviainen T;Payton A;Pazoki R;Petrovic K;Reynolds CA;Sargurupremraj M;Scholz M;Smith JA;Smith AV;Terzikhan N;Thalamuthu A;Trompet S;van der Lee SJ;Ware EB;Windham BG;Wright MJ;Yang J;Yu J;Ames D;Amin N;Amouyel P;Andreassen OA;Armstrong NJ;Assareh AA;Attia JR;Attix D;Avramopoulos D;Bennett DA;Böhmer AC;Boyle PA;Brodaty H;Campbell H;Cannon TD;Cirulli ET;Congdon E;Conley ED;Corley J;Cox SR;Dale AM;Dehghan A;Dick D;Dickinson D;Eriksson JG;Evangelou E;Faul JD;Ford I;Freimer NA;Gao H;Giegling I;Gillespie NA;Gordon SD;Gottesman RF;Griswold ME;Gudnason V;Harris TB;Hartmann AM;Hatzimanolis A;Heiss G;Holliday EG;Joshi PK;Kähönen M;Kardia SLR;Karlsson I;Kleineidam L;Knopman DS;Kochan NA;Konte B;Kwok JB;Le Hellard S;Lee T;Lehtimäki T;Li SC;Lill CM;Liu T;Koini M;London E;Longstreth WT Jr;Lopez OL;Loukola A;Luck T;Lundervold AJ;Lundquist A;Lyytikäinen LP;Martin NG;Montgomery GW;Murray AD;Need AC;Noordam R;Nyberg L;Ollier W;Papenberg G;Pattie A;Polasek O;Poldrack RA;Psaty BM;Reppermund S;Riedel-Heller SG;Rose RJ;Rotter JI;Roussos P;Rovio SP;Saba Y;Sabb FW;Sachdev PS;Satizabal CL;Schmid M;Scott RJ;Scult MA;Simino J;Slagboom PE;Smyrnis N;Soumaré A;Stefanis NC;Stott DJ;Straub RE;Sundet K;Taylor AM;Taylor KD;Tzoulaki I;Tzourio C;Uitterlinden A;Vitart V;Voineskos AN;Kaprio J;Wagner M;Wagner H;Weinhold L;Wen KH;Widen E;Yang Q;Zhao W;Adams HHH;Arking DE;Bilder RM;Bitsios P;Boerwinkle E;Chiba-Falek O;Corvin A;De Jager PL;Debette S;Donohoe G;Elliott P;Fitzpatrick AL;Gill M;Glahn DC;Hägg S;Hansell NK;Hariri AR;Ikram MK;Jukema JW;Vuoksimaa E;Keller MC;Kremen WS;Launer L;Lindenberger U;Palotie A;Pedersen NL;Pendleton N;Porteous DJ;Räikkönen K;Raitakari OT;Ramirez A;Reinvang I;Rudan I;Dan Rujescu;Schmidt R;Schmidt H;Schofield PW;Schofield PR;Starr JM;Steen VM;Trollor JN;Turner ST;Van Duijn CM;Villringer A;Weinberger DR;Weir DR;Wilson JF;Malhotra A;McIntosh AM;Gale CR;Seshadri S;Mosley TH Jr;Bressler J;Lencz T;Deary IJ
通讯作者：
Deary IJ