The effects of artificially induced proestrus on heroin intake: A critical role for estradiol.
The effects of artificially induced proestrus on heroin intake: A critical role for estradiol.
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DOI：
10.1037/pha0000428
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发表时间：
2022-04
影响因子：
2.3
通讯作者：
Sharp JL
中科院分区：
文献类型：
--
作者：
Smith MA;Ethridge SB;Gibson AN;Schmidt KT;Sharp JL
在正常周期雌性大鼠的发情前期，海洛因摄入量明显减少;然而，目前尚不清楚雌二醇、孕酮或这两种激素是否导致海洛因摄入量减少。本研究的目的是探讨雌二醇和孕酮在海洛因摄入的作用，通过人工诱导动情前期状态在卵巢切除大鼠。为此，卵巢切除的雌性大鼠植入静脉导管，并训练以固定比例（FR 1）强化时间表自我给予海洛因（0.0075 mg/kg/输注）。训练一周后，在试验期前22小时用雌二醇（0.005 mg，sc）或赋形剂，在试验期前0.5小时用孕酮（0.125 mg，sc）或赋形剂，以人工模拟自然发生的晚动情前期特征性激素浓度，以每周一次的间隔对大鼠进行试验。试验前22小时给予雌二醇，试验前0.5小时给予孕酮，与前一训练日和对照组相比，可显著降低海洛因摄入量。有趣的是，当仅给予雌二醇而不是孕酮时，观察到相同的效果。这些数据表明，雌二醇，而不是孕激素是负责的发情前期诱导的海洛因摄入量减少以前报道的正常循环的雌性大鼠。这些研究结果与先前报道的兴奋剂不同，表明基于雌激素的药物治疗可能对阿片类药物使用障碍的女性有价值。
Heroin intake decreases markedly during proestrus in normally cycling female rats; however, it is not known whether estradiol, progesterone, or both hormones are responsible for these decreases in heroin intake. The purpose of the present study was to examine the roles of estradiol and progesterone in heroin intake by artificially inducing a proestrus state in ovariectomized rats. To this end, ovariectomized female rats were implanted with intravenous catheters and trained to self-administer heroin (0.0075 mg/kg/infusion) on a fixed ratio (FR1) schedule of reinforcement. After one week of training, rats were tested at weekly intervals with estradiol (0.005 mg, sc) or vehicle 22 hr before a test session and progesterone (0.125 mg, sc) or vehicle 0.5 hr before a test session to artificially mimic the naturally occurring hormone concentrations characteristic of late proestrus. Administration of estradiol 22 hr prior to testing and progesterone 0.5 hr prior to testing significantly reduced heroin intake relative to the previous training day and vehicle control. Interestingly, this same effect was observed when only estradiol, but not progesterone, was administered. These data suggest that estradiol but not progesterone is responsible for the proestrus-induced decreases in heroin intake previously reported in normally cycling female rats. These findings differ from those reported previously with stimulants and suggest that estrogen-based pharmacotherapies may be of value in women with opioid use disorder.
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性别，发情周期和社会接触对大鼠可卡因和海洛因自我管理的影响。
影响因子：
3.4
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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