Loss in connectivity among regions of the brain reward system in alcohol dependence.
Loss in connectivity among regions of the brain reward system in alcohol dependence.
复制标题
DOI：
10.1002/hbm.22132
复制
发表时间：
2013-12
影响因子：
4.8
通讯作者：
Raj, Ashish
中科院分区：
文献类型：
--
作者：
Kuceyeski, Amy;Meyerhoff, Dieter J.;Durazzo, Timothy C.;Raj, Ashish
关键词：
最近开发的结构性脑连接中断的措施，在连接（LOCO）的损失，适用于酒精依赖的研究。LoCo使用来自年轻健康对照的独立纤维束成像信息，将酒精依赖与非依赖个体中白色物质微结构异常的位置投影到连接的灰质区域上。根据在两个水平上获得的白色异常掩码计算LoCo评分：1）酒精依赖个体与轻度饮酒对照组的组间差异，以及2）酒精依赖个体与轻度饮酒对照组的差异。基于组间白色物质差异的LoCo分数显示，属于扩展的大脑奖励系统网络（BRS）的灰质区域具有显著更高的LoCo（即，断开连接）的患者比不在该网络中的患者多（t = 2.18，p = 0.016）。基于个体白色物质差异的局部得分在酒精依赖个体中也高于非BRS（t = 5.26，p = 3.92×10−6）。这些结果表明，酒精依赖的白色物质的改变，虽然微妙的和空间异质性的人口，但优先本地化的BRS。通过区分酒精依赖者和非酒精对照者的大脑，LoCo比传统的体积灰质测量提供了更敏感的灰质参与估计（89.3%对69.6%）。然而，就像容积测量一样，LoCo与标准饮酒严重程度测量没有显着相关性。LOCO是一个敏感的白色物质测量区域皮质的断开，独特的特点解剖网络中断酒精依赖。
A recently developed measure of structural brain connectivity disruption, the Loss in Connectivity (LoCo), is adapted for studies in alcohol dependence. LoCo uses independent tractography information from young healthy controls to project the location of white matter microstructure abnormalities in alcohol dependent vs. non-dependent individuals onto connected gray matter regions. The LoCo scores are computed from white matter abnormality masks derived at two levels: 1) group-wise differences of alcohol dependent individuals versus light drinking controls and 2) differences of the alcohol dependent individual versus the light drinking control group. LoCo scores based on group-wise white matter differences show that gray matter regions belonging to the extended brain reward system-network (BRS) have significantly higher LoCo (i.e., disconnectivity) than those not in this network (t = 2.18, p = 0.016). LoCo scores based on individuals’ white matter differences are also higher in BRS vs. non-BRS (t = 5.26, p = 3.92×10−6) of alcohol dependent individuals. These results suggest that white matter alterations in alcohol dependence, although subtle and spatially heterogeneous across the population, are nonetheless preferentially localized to the BRS. LoCo is shown to provide a more sensitive estimate of gray matter involvement than conventional volumetric gray matter measures, by differentiating better between brains of alcohol dependent individuals and non-alcoholic controls (rates of 89.3% versus 69.6%). However, just as volumetric measures, LoCo is not significantly correlated with standard drinking severity measures. LoCo is a sensitive white matter measure of regional cortical disconnectivity that uniquely characterizes anatomical network disruptions in alcohol dependence.
登录
查看更多内容
影响因子：
8.2
作者：
George, Olivier;Koob, George F.
通讯作者：
Koob, George F.
影响因子：
5.7
作者：
Gold, Brian T.;Powell, David K.;Andersen, Anders H.;Smith, Charles D.
通讯作者：
Smith, Charles D.
DOI：
10.1111/j.1530-0277.2011.01452.x
发表时间：
2011-06
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Durazzo TC;Tosun D;Buckley S;Gazdzinski S;Mon A;Fryer SL;Meyerhoff DJ
通讯作者：
Meyerhoff DJ
影响因子：
3.3
作者：
Griswold, MA;Jakob, PM;Haase, A
通讯作者：
Haase, A
DOI：
10.1097/01.alc.0000148112.92525.ac
发表时间：
2004-12-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Durazzo, TC;Gazdzinski, S;Meyerhoff, DJ
通讯作者：
Meyerhoff, DJ