Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.
Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.
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外侧膝状核离散区域内广泛的视锥相关光谱对抗，支持小鼠的色觉。
DOI：
10.1016/j.cub.2021.05.024
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发表时间：
2021-08-09
期刊：
影响因子：
--
通讯作者：
Brown TM
中科院分区：
文献类型：
--
作者：
Mouland JW;Pienaar A;Williams C;Watson AJ;Lucas RJ;Brown TM
色觉起源于对不同光谱的光感受器信号的对立加工，在动物行为中起着重要的作用。然而，令人惊讶的是，人们对大脑中的颜色处理知之甚少，包括广泛使用的实验室哺乳动物，如小鼠。传统上认为S-和M-视锥视蛋白（共）表达的视网膜梯度是小鼠色觉的障碍。然而，最近的数据表明，小鼠表现出强大的颜色歧视内的中央上视野。据报道，视网膜颜色重叠是由于在视锥视蛋白表达梯度上叠加抑制性周围感受野，以及通过在具有稀疏M-视锥视蛋白表达的视网膜区域中引入对手视杆信号而出现的。这些建议的机制在确定更高的视觉处理阶段的神经元的属性的相对重要性仍然未知。我们解决这些问题，使用多电极记录从外侧膝状体核（LGN）在小鼠改变M-锥光谱灵敏度（Opn 1 mwR）和多光谱刺激，允许选择性调制信号的个别视蛋白类。值得注意的是，我们发现许多（约25%）LGN细胞是颜色对手，这些细胞被定位到一个独特的中间LGN区，他们的属性不能简单地解释所提出的视网膜对手机制。LGN中的对立反应可以仅由视锥驱动，独立于视锥视蛋白表达梯度和视杆输入，许多细胞表现出空间一致的拮抗感受野。因此，我们的数据表明，以前未确定的机制可能支持广泛和复杂的颜色处理在小鼠LGN。在小鼠LGN中，色区内的神经元之间的颜色一致性是常见的。到LGN的锥体输入在中间视觉到明视光水平上驱动颜色一致性。到对手神经元的锥体输入来源于中央和上视野。研究小鼠视丘的颜色处理过程。他们表明，颜色识别在外侧膝状体核的特定区域内的细胞中广泛存在，并且视锥驱动这种反应，独立于视锥视蛋白表达梯度和视杆输入，为小鼠的颜色识别提供了强大的能力。
Color vision, originating with opponent processing of spectrally distinct photoreceptor signals, plays important roles in animal behavior. Surprisingly, however, comparatively little is understood about color processing in the brain, including in widely used laboratory mammals such as mice. The retinal gradient in S- and M-cone opsin (co-)expression has traditionally been considered an impediment to mouse color vision. However, recent data indicate that mice exhibit robust chromatic discrimination within the central-upper visual field. Retinal color opponency has been reported to emerge from superimposing inhibitory surround receptive fields on the cone opsin expression gradient, and by introducing opponent rod signals in retinal regions with sparse M-cone opsin expression. The relative importance of these proposed mechanisms in determining the properties of neurons at higher visual processing stages remains unknown. We address these questions using multielectrode recordings from the lateral geniculate nucleus (LGN) in mice with altered M-cone spectral sensitivity (Opn1mwR) and multispectral stimuli that allow selective modulation of signaling by individual opsin classes. Remarkably, we find many (∼25%) LGN cells are color opponent, that such cells are localized to a distinct medial LGN zone and that their properties cannot simply be explained by the proposed retinal opponent mechanisms. Opponent responses in LGN can be driven solely by cones, independent of cone-opsin expression gradients and rod input, with many cells exhibiting spatially congruent antagonistic receptive fields. Our data therefore suggest previously unidentified mechanisms may support extensive and sophisticated color processing in the mouse LGN. Color opponency is common among neurons within a chromatic zone in the mouse LGN Cone inputs to LGN drive color opponency across mesopic to photopic light levels Cone inputs to opponent neurons derive from central and upper visual field Subsets of LGN neurons display opponency for small or large stimuli only Mouland et al. examine color processing in the mouse visual thalamus. They show that color opponency is widespread among cells within a specific zone of the lateral geniculate nucleus and that cones drive such responses, independent of cone-opsin expression gradients and rod input, providing a robust capacity for color discrimination in mice.
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影响因子：
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