Higher-Order Inputs Involved in Appetite Control.
Higher-Order Inputs Involved in Appetite Control.
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DOI：
10.1016/j.biopsych.2021.07.015
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发表时间：
2022-05-15
影响因子：
10.6
通讯作者：
Stern, Sarah A.
中科院分区：
文献类型：
--
作者：
Azevedo, Estefania P.;Ivan, Violet J.;Friedman, Jeffrey M.;Stern, Sarah A.
对食欲的神经控制的理解有助于了解神经性厌食症和肥胖等饮食失调的发病机制。这两种疾病都是不适应饮食行为（暴饮暴食或饮食不足）的结果，并与危及生命的健康问题有关。食欲的精细调节涉及遗传、生理和环境因素，这些因素被特定的神经元群检测并整合到大脑中。几个世纪以来，下丘脑一直是科学界关注的焦点，因为它是食欲的关键调节器。下丘脑接收并发送轴突投射到大脑的其他几个区域，这些区域对感觉和情感信息的整合很重要。这些联系确保了根据个人的情绪状态和环境做出适当的行为决定。因此，高阶脑区整合外感信息以协调摄食的机制非常重要。在这篇综述中，我们将重点关注连接下丘脑与边缘系统和皮层高阶大脑中心的功能和解剖投影。我们还将讨论位于高阶中枢的特定神经元群调节食欲的机制，以及皮层和皮层下区域与下丘脑之间连接的改变如何引起不适应的饮食行为。
The understanding of the neural control of appetite sheds light into the pathogenesis of eating disorders, such as anorexia nervosa and obesity. Both diseases are a result of maladaptive eating behaviors (overeating or undereating) and associated with life-threatening health problems. The fine regulation of appetite involves genetic, physiological and environmental factors which are detected and integrated in the brain by specific neuronal populations. For centuries, the hypothalamus has been the center of attention in the scientific community as a key regulator of appetite. The hypothalamus receives and sends axonal projections to several other brain regions that are important for the integration of sensory and emotional information. These connections ensure that appropriate behavioral decisions are made depending on the individual’s emotional state and environment. Thus, the mechanisms by which higher-order brain regions integrate exteroceptive information to coordinate feeding is of great importance. In this review, we will focus on the functional and anatomical projections connecting the hypothalamus to the limbic system and higher-order brain centers in the cortex. We will also address the mechanisms by which specific neuronal populations located in higher-order centers regulate appetite and how maladaptive eating behaviors might arise from altered connections among cortical and subcortical areas with the hypothalamus.
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影响因子：
64.5
作者：
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