Multisynaptic Projections from the Amygdala to the Ventral Premotor Cortex in Macaque Monkeys: Anatomical Substrate for Feeding Behavior.
Multisynaptic Projections from the Amygdala to the Ventral Premotor Cortex in Macaque Monkeys: Anatomical Substrate for Feeding Behavior.
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从杏仁核到猕猴的腹侧前皮层的多突触投影：用于喂养行为的解剖基板。
DOI：
10.3389/fnana.2018.00003
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发表时间：
2018
影响因子：
2.9
通讯作者：
Takada M
中科院分区：
文献类型：
--
作者：
Ishida H;Inoue KI;Takada M
杏仁核编码进食行为的视觉味觉/躯体感觉效价。另一方面，腹侧前运动皮层（PMv）在觅食行为的前提条件下，达到和把握动作起着核心作用。这意味着，来自杏仁核的对象价信号可能是至关重要的喂养相关的电机动作施加PMV。然而，由于杏仁核和PMv之间没有直接的连接已经报道，它们的功能相互作用的结构基础仍然难以捉摸。在本研究中，我们采用逆行transneuronal标记与狂犬病病毒，以确定杏仁核的起源和可能的路线的多突触投射到PMV在猕猴。对标记神经元分布模式的组织学分析发现，PMv主要从基底核，特别是其中间亚核接受双突触输入。还已经揭示，内侧（例如，扣带运动区，CMA）和外侧（例如，岛叶皮质区和基底前脑胆碱能细胞群4可能介导杏仁核向PMv的投射。这种多突触通路可能代表杏仁核对PMv摄食行为功能的影响。
The amygdala codes the visual-gustatory/somatosensory valence for feeding behavior. On the other hand, the ventral premotor cortex (PMv) plays a central role in reaching and grasping movements prerequisite for feeding behavior. This implies that object valence signals derived from the amygdala may be crucial for feeding-related motor actions exerted by PMv. However, since no direct connectivity between the amygdala and PMv has been reported, the structural basis of their functional interactions still remains elusive. In the present study, we employed retrograde transneuronal labeling with rabies virus to identify the amygdalar origin and possible route of multisynaptic projections to PMv in macaque monkeys. Histological analysis of the distribution pattern of labeled neurons has found that PMv receives disynaptic input primarily from the basal nucleus, especially from its intermediate subdivision. It has also been revealed that the medial (e.g., the cingulate motor areas, CMA) and lateral (e.g., the insular cortices) cortical areas, and the cholinergic cell group 4 in the basal forebrain probably mediate the projections from the amygdala to PMv. Such multisynaptic pathways might represent amygdalar influences on PMv functions for feeding behavior.
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影响因子：
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作者：
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通讯作者：
Luppino, Giuseppe
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