Swertiamarin ameliorates diet-induced obesity by promoting adipose tissue browning and oxidative metabolism in preexisting obese mice.
Swertiamarin ameliorates diet-induced obesity by promoting adipose tissue browning and oxidative metabolism in preexisting obese mice.
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獐牙菜苦苷通过促进先前存在的肥胖小鼠的脂肪组织褐变和氧化代谢来改善饮食引起的肥胖
DOI：
10.3724/abbs.2022154
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发表时间：
2022-10-25
影响因子：
3.7
通讯作者：
Xu L
中科院分区：
文献类型：
--
作者：
Zhu Y;Li H;Ma M;Li D;Zhang O;Cai S;Wang Y;Chen D;Jin S;Ding C;Xu L
肥胖是许多代谢性疾病的危险因素。迫切需要有效的治疗策略。獐牙菜苦苷 (STM) 可预防肥胖以及相关的胰岛素抵抗和炎症。然而，STM 对既往肥胖的治疗效果仍不清楚。因此，在这项研究中，我们旨在研究 STM 对既往肥胖小鼠的能量消耗和脂肪褐变的影响。 C57BL/6J 小鼠用高脂饮食 (HFD) 喂养 8 周以诱导肥胖，然后用 STM 灌胃（或不灌胃）10 周。通过间接量热法检查小鼠的全身能量代谢。结果显示，治疗 10 周后，STM 显着预防 HFD 引起的体重增加、慢性炎症、胰岛素抵抗和肝脂肪变性。 STM 促进氧气消耗和能量消耗。 STM 处理小鼠的棕色和白色脂肪组织中解偶联蛋白 1 的水平有所增强。 STM 增加 AMP 激活蛋白激酶的磷酸化和参与脂肪氧化的基因的表达，减少骨骼肌中的脂肪沉积。同时，STM不影响肠道微生物组成。总体而言，STM 补充剂可能作为肥胖症的潜在疗法。
Obesity is a risk factor for many metabolic diseases. Efficient therapeutic strategies are urgently needed. Swertiamarin (STM) prevents obesity and the associated insulin resistance and inflammation. However, the therapeutic effects of STM on preexisting obesity remain unclear. Therefore, in this study we aim to investigate the effects of STM on energy expenditure and fat browning in mice with preexisting obesity. C57BL/6J mice are fed with a high-fat diet (HFD) for 8 weeks to induce obesity and then gavaged (or not) with STM for 10 weeks. The whole-body energy metabolism of mice is examined by indirect calorimetry. The results show that after 10 weeks of treatment, STM markedly prevents HFD-induced weight gain, chronic inflammation, insulin resistance, and hepatic steatosis. STM promotes oxygen consumption and energy expenditure. The level of uncoupling protein 1 is enhanced in the brown and white adipose tissues of STM-treated mice. STM increases the phosphorylation of AMP-activated protein kinase and the expressions of genes involved in fat oxidation, reducing fat deposition in skeletal muscles. Meanwhile, STM does not affect the intestinal microbiotic composition. Overall, STM supplementation may serve as a potential therapy for obesity.
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影响因子：
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