The Potential Intermediate Hosts for SARS-CoV-2.
The Potential Intermediate Hosts for SARS-CoV-2.
复制标题
SARS-CoV-2 的潜在中间宿主
DOI：
10.3389/fmicb.2020.580137
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发表时间：
2020
影响因子：
5.2
通讯作者：
Tian BP
中科院分区：
文献类型：
--
作者：
Zhao J;Cui W;Tian BP
由严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）引起的冠状病毒病19 (COVID-19)，自武汉首次报告以来，已成为全球大流行。COVID-19是一种人畜共患疾病，SARS-CoV-2的天然宿主似乎是蝙蝠。然而，解释其传播和进化的中间宿主尚不清楚。除了野生动物在自然生态环境中与蝙蝠接触，进而在野生动物市场感染人类外，家畜在感染SARS-CoV-2后也能确立自己作为中间宿主的地位。尽管最近与SARS-CoV-2相关的研究取得了很大进展，但许多关键问题仍未得到解决。在此，我们回顾了有关中间宿主研究的发现，这可能会启发未来的研究者并为他们提供大量的信息。结果表明中间宿主在SARS-CoV-2传播链中的关键作用，并在此基础上进行有效干预，可能有助于防止COVID-19进一步恶化。
The coronavirus disease 19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic since the first report in Wuhan. COVID-19 is a zoonotic disease and the natural reservoir of SARS-CoV-2 seems to be bats. However, the intermediate host explaining the transmission and evolvement is still unclear. In addition to the wildlife which has access to contact with bats in the natural ecological environment and then infects humans in wildlife market, domestic animals are also able to establish themselves as the intermediate host after infected by SARS-CoV-2. Although recent studies related to SARS-CoV-2 have made a lot of progress, many critical issues are still unaddressed. Here, we reviewed findings regarding the investigations of the intermediate host, which may inspire future investigators and provide them with plenty of information. The results demonstrate the critical role of the intermediate host in the transmission chain of SARS-CoV-2, and the efficient intervention on this basis may be useful to prevent further deterioration of COVID-19.
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DOI：
10.1038/nrmicro.2016.81
发表时间：
2016-08
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
de Wit E;van Doremalen N;Falzarano D;Munster VJ
通讯作者：
Munster VJ
影响因子：
12.7
作者：
Ji, Wei;Wang, Wei;Li, Xingguang
通讯作者：
Li, Xingguang
影响因子：
4.3
作者：
Deng, Junhua;Jin, Yipeng;Tian, Kegong
通讯作者：
Tian, Kegong
SARS-CoV-2受体ACE2基因表达和调控的个体差异
影响因子：
7.8
作者：
Chen, Jiawei;Jiang, Quanlong;Han, Jing-Dong J.
通讯作者：
Han, Jing-Dong J.
影响因子：
30.3
作者：
Kim, Young-Il;Kim, Seong-Gyu;Choi, Young Ki
通讯作者：
Choi, Young Ki