Recent Advances and Opportunities in the Study of Candida albicans Polymicrobial Biofilms.
Recent Advances and Opportunities in the Study of Candida albicans Polymicrobial Biofilms.
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DOI：
10.3389/fcimb.2022.836379
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发表时间：
2022
影响因子：
5.7
通讯作者：
Pohl CH
中科院分区：
文献类型：
--
作者：
Pohl CH
众所周知，机会致病酵母菌白色念珠菌在体外和体内都能与多种细菌形成多微生物生物膜，这些多微生物生物膜可以影响疾病的进程和治疗。尽管具体的相互作用通常被描述为协同或拮抗，但这可能是过于简单化了。多菌生物膜是一个复杂的双向相互作用的群落，受域间(域间)信号和各种分子机制的调控。这篇综述文章将重点介绍过去六年(2016-2021年)在由白色念珠菌和细菌形成的多微生物生物膜的独特生物学方面的进展，包括对它们形成的调控。此外，还将讨论这些相互作用的一些后果，例如共存对抗菌素敏感性和毒力的影响。由于这一知识的目的是提供可能的替代治疗选择，因此也将包括最近发现的新型抗生物被膜化合物的研究。在整个过程中，将努力查明这一领域正在面临的挑战。
It is well known that the opportunistic pathogenic yeast, Candida albicans, can form polymicrobial biofilms with a variety of bacteria, both in vitro and in vivo, and that these polymicrobial biofilms can impact the course and management of disease. Although specific interactions are often described as either synergistic or antagonistic, this may be an oversimplification. Polymicrobial biofilms are complex two-way interacting communities, regulated by inter-domain (inter-kingdom) signaling and various molecular mechanisms. This review article will highlight advances over the last six years (2016-2021) regarding the unique biology of polymicrobial biofilms formed by C. albicans and bacteria, including regulation of their formation. In addition, some of the consequences of these interactions, such as the influence of co-existence on antimicrobial susceptibility and virulence, will be discussed. Since the aim of this knowledge is to inform possible alternative treatment options, recent studies on the discovery of novel anti-biofilm compounds will also be included. Throughout, an attempt will be made to identify ongoing challenges in this area.
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影响因子：
11.3
作者：
d'Enfert C;Kaune AK;Alaban LR;Chakraborty S;Cole N;Delavy M;Kosmala D;Marsaux B;Fróis-Martins R;Morelli M;Rosati D;Valentine M;Xie Z;Emritloll Y;Warn PA;Bequet F;Bougnoux ME;Bornes S;Gresnigt MS;Hube B;Jacobsen ID;Legrand M;Leibundgut-Landmann S;Manichanh C;Munro CA;Netea MG;Queiroz K;Roget K;Thomas V;Thoral C;Van den Abbeele P;Walker AW;Brown AJP
通讯作者：
Brown AJP
影响因子：
2.7
作者：
Chinnici, Jennifer;Yerke, Lisa;Maddi, Abhiram
通讯作者：
Maddi, Abhiram
影响因子：
3.7
作者：
Delben JA;Zago CE;Tyhovych N;Duarte S;Vergani CE
通讯作者：
Vergani CE
影响因子：
4.6
作者：
Bartnicka, Dominika;Karkowska-Kuleta, Justyna;Rapala-Kozik, Maria
通讯作者：
Rapala-Kozik, Maria
影响因子：
3.8
作者：
Cernakova, L.;Jordao, L.;Bujdakova, H.
通讯作者：
Bujdakova, H.