Invasive Mucinous Adenocarcinoma of the Lung With a Mural Nodule-like Lesion
Invasive Mucinous Adenocarcinoma of the Lung With a Mural Nodule-like Lesion
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具有附壁结节样病变的肺浸润性粘液腺癌
DOI：
10.1097/pas.0000000000001938
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发表时间：
2022
期刊：
影响因子：
5.6
通讯作者：
Watanabe S. I. and Yatabe Y.
中科院分区：
文献类型：
--
作者：
Higashiyama M.;Kobayashi Y.;Kashima J.;Muraoka Y.;Watanabe H.;Kusumoto M.;Watanabe S. I. and Yatabe Y.
肺浸润性粘液腺癌（IMA）与其他器官（如卵巢）的粘液腺癌有一些共同的临床病理特征。肉瘤样病变，称为壁结节，已报告在卵巢粘液性肿瘤的囊壁。在这项研究中，我们分析了213例经手术切除的肺IMA，以确定是否存在类似的壁结节样病变。我们认为由去分化的肿瘤细胞组成的突然离散病变为壁结节样病变。在213例IMA中，我们发现了11例具有壁结节样病变的肿瘤，这些肿瘤在组织学上分为三个亚型，与卵巢中的亚型相似。肉瘤样和间变性癌样结节分别由梭形细胞增生和多边形未分化癌组成。肉瘤样病变模仿肉瘤样结节，但梭形细胞增殖被认为是成纤维细胞反应的分散，孤立的肿瘤细胞簇。分化的IMA和壁结节样病变的成分的分子分析揭示了克隆的关系，表明不同组织学的肿瘤谱。在临床病理学上，年龄较大、男性和吸烟者与伴壁结节样病变的IMA显著相关。值得注意的是，患者结局不受这些病变存在与否的影响。我们的研究结果表明，IMA的肺很少发展壁结节样病变（11/213，5%）。尽管组织学印象的临床侵略性，没有明确的趋势，患者的结果，这表明病理学家应避免夸大这种壁结节样病变。
Invasive mucinous adenocarcinoma (IMA) of the lung shares some clinicopathological features with mucinous carcinoma of other organs, such as the ovary. Sarcoma-like lesions, called mural nodules, have been reported in the cystic walls of ovarian mucinous tumors. In this study, we analyzed 213 surgically resected cases of IMA of the lung to determine whether similar mural nodule–like lesions were present. We considered abrupt discrete lesions composed of dedifferentiated tumor cells as mural nodule–like lesions. Of 213 IMAs, we identified 11 tumors with mural nodule–like lesions that were histologically categorized into three subtypes similar to those in the ovary. The sarcomatoid and anaplastic carcinoma–like nodules were composed of spindle cell proliferations and polygonal undifferentiated carcinoma, respectively. Sarcoma-like lesions mimicked sarcomatoid nodules, but the spindle cell proliferations were considered a fibroblastic reaction to the scattered, isolated clusters of tumor cells. Molecular analysis of the components of differentiated IMAs and mural nodule–like lesions revealed a clonal relationship, suggesting a spectrum of tumors with different histology. Clinicopathologically, an older age, the male sex, and smokers were significantly associated with IMAs with mural nodule–like lesions. Notably, patient outcomes were unaffected by the presence or absence of these lesions. Our findings demonstrated that IMA of the lung rarely develops mural nodule–like lesions (11 of 213, 5%). Despite a histological impression of clinical aggressiveness, there was no clear trend in patient outcomes, suggesting that pathologists should avoid overstating this mural nodule–like lesion.
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阑尾粘液性囊腺癌，伴有间变性癌壁结节和 K-RAS 突变。
DOI：
10.5152/tjg.2018.17738
发表时间：
2018
期刊：
The Turkish Journal of Gastroenterology
影响因子：
--
作者：
G. Kir;B. Sarbay;B. Girgin;Filiz Özen
通讯作者：
Filiz Özen
影响因子：
3.3
作者：
GOLDBERG, RD;MICHELASSI, F;MONTAG, AG
通讯作者：
MONTAG, AG
胰腺未分化癌：中间丝轮廓和 Ki-ras 突变的分析提供了导管起源的证据
影响因子：
7.3
作者：
A. Hoorens;K. Prenzel;N. Lemoine;G. Klöppel
通讯作者：
G. Klöppel
影响因子：
1.2
作者：
Fujii K;Nitta T;Kawasaki H;Kataoka J;Tominaga T;Inoue Y;Kadota E;Ishibashi T;Uchiyama K
通讯作者：
Uchiyama K
影响因子：
5.6
作者：
Bagué, S;Rodríguez, IM;Prat, J
通讯作者：
Prat, J