The infant microbiome development: mom matters.

The infant microbiome development: mom matters.
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DOI:
10.1016/j.molmed.2014.12.002
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发表时间:
2015-02
影响因子:
13.6
通讯作者:
Dominguez-Bello MG
Dominguez-Bello MG
中科院分区:
医学1区
文献类型:
--
作者:
Mueller NT;Bakacs E;Combellick J;Grigoryan Z;Dominguez-Bello MG

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婴儿微生物组在人类健康中起着至关重要的作用,其组装是由母体-后代的微生物组交换决定的。这一过程受到几种做法的影响,包括剖腹产、围产期抗生素和配方奶粉喂养,这些做法与代谢和免疫疾病的风险增加有关。在这里,我们回顾了有关婴儿微生物组组装影响的最新知识,讨论了改善这些影响的预防和恢复策略,并强调了推进这一领域和改善后代健康所需的研究。
The infant microbiome plays an essential role in human health and its assembly is determined by maternal– offspring exchanges of microbiota. This process is affected by several practices, including Cesarean section (C-section), perinatal antibiotics, and formula feeding, that have been linked to increased risks of metabolic and immune diseases. Here we review recent knowledge about the impacts on infant microbiome assembly, discuss preventive and restorative strategies to ameliorate the effects of these impacts, and highlight where research is needed to advance this field and improve the health of future generations.
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