Extracellular vesicles and their role in gestational diabetes mellitus.
Extracellular vesicles and their role in gestational diabetes mellitus.
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DOI：
10.1016/j.placenta.2021.02.012
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发表时间：
2021-09-15
期刊：
影响因子：
3.8
通讯作者：
Devaskar SU
中科院分区：
文献类型：
--
作者：
James-Allan LB;Devaskar SU
妊娠期糖尿病（GDM）是一种以妊娠期葡萄糖耐受不良为特征的复杂疾病。GDM的发病率在世界范围内呈上升趋势。妊娠合并GDM的孕妇和胎儿发病率较高，具有短期和长期后果，包括母亲和后代心血管疾病和II型糖尿病的发病率增加。GDM的病理生理学尚不清楚，人们对小细胞外囊泡（sev）在妊娠期和GDM发生的母体代谢适应中的作用很感兴趣。小型电动汽车是含有生物活性成分的纳米级颗粒，包括mirna和蛋白质，它们由细胞释放以提供细胞间的通信。妊娠诱导妊娠期间总sEV和胎盘分泌sEV的增加，并进一步增加sEV数量，改变GDM中这些sEV的蛋白质和miRNA组成。研究表明，这些sev对孕妇怀孕期间的适应有影响，包括针对胰腺、骨骼肌和脂肪组织。因此，本文将重点讨论GDM患者与正常妊娠相比总sev和胎盘sev的差异，sev在GDM病理生理中的作用及其作为潜在GDM生物标志物的临床应用。
Gestational diabetes mellitus (GDM) is a complex disorder that is defined by glucose intolerance with onset during pregnancy. The incidence of GDM is increasing worldwide. Pregnancies complicated with GDM have higher rates of maternal and fetal morbidity with short- and long-term consequences, including increased rates of cardiovascular disease and type II diabetes for both the mother and offspring. The pathophysiology of GDM still remains unclear and there has been interest in the role of small extracellular vesicles (sEVs) in the maternal metabolic adaptations that occur in pregnancy and GDM. Small EVs are nanosized particles that contain bioactive content, including miRNAs and proteins, which are released by cells to provide cell-to-cell communication. Pregnancy induces an increase in total and placental-secreted sEVs across gestation, with a further increase in sEV number and changes in the protein and miRNA composition of these sEVs in GDM. Research has suggested that these sEVs have an impact on maternal adaptations during pregnancy, including targeting the pancreas, skeletal muscle and adipose tissue. Consequently, this review will focus on the differences in total and placental sEVs in GDM compared to normal pregnancy, the role of sEVs in the pathophysiology of GDM and their clinical application as potential GDM biomarkers.
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影响因子：
3.7
作者：
Boyle KE;Hwang H;Janssen RC;DeVente JM;Barbour LA;Hernandez TL;Mandarino LJ;Lappas M;Friedman JE
通讯作者：
Friedman JE
影响因子：
16.2
作者：
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DOI：
10.1016/j.bbrc.2010.04.116
发表时间：
2010-05-28
影响因子：
3.1
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3.1
作者：
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影响因子：
5.5
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England LJ