Cigarette smoking is associated with cortical thinning in anterior frontal regions, insula and regions showing atrophy in early Alzheimer's Disease.
Cigarette smoking is associated with cortical thinning in anterior frontal regions, insula and regions showing atrophy in early Alzheimer's Disease.
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DOI：
10.1016/j.drugalcdep.2018.08.009
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发表时间：
2018-11-01
影响因子：
4.2
通讯作者：
Yoder KK
中科院分区：
文献类型：
--
作者：
Durazzo TC;Meyerhoff DJ;Yoder KK
关于吸烟对人类大脑结构影响的磁共振成像研究主要集中在皮质体积上。人们对吸烟对皮质厚度的影响知之甚少。吸烟者和不吸烟者的局部皮质厚度进行了比较。我们预测吸烟者将表现出更大的年龄相关性变薄，定位于作为执行、突出和情绪调节网络(ESER区域)节点的前额叶区域，以及那些在早期阿尔茨海默病(AD区域)表现出显著萎缩的区域。非吸烟者(n=41)和吸烟者(n=41)，年龄22-70岁，完成了4T磁共振研究。通过Freesurfer对局部皮质厚度进行定量。在吸烟者中，研究了吸烟严重程度、决策、冲动和局部皮质厚度之间的关系。吸烟者在内侧和外侧OFC、岛叶、内嗅区、梭形区、中颞区和复合型AD区表现出皮质变薄。在吸烟者中，更大的背包年数与较薄的外侧OFC区、中颞区、顶下区、梭形区、楔前区和复合型AD区相关。在吸烟者中，较差的决策/较大的风险与ACC尾侧、额中上回和复合ESER的皮质变薄有关。较高的自我报告冲动与较薄的肩部和尾部ACC有关。这项研究提供了额外的证据，表明吸烟与皮质变薄有关，在与物质使用障碍的发展和维持有关的区域，以及在AD早期表现出显著萎缩的区域。吸烟者的新结构-功能关系进一步加深了我们对吸烟者神经心理异常潜在潜在神经生物学基础的理解。
Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure primarily focused on cortical volumes. Much less is known about the effects of smoking on cortical thickness. Smokers and Non-smokers were compared on regional cortical thickness. We predicted smokers would demonstrate greater age-related thinning localized to anterior frontal regions that serve as nodes for the executive, salience, and emotional regulation networks (ESER regions) and those demonstrating significant atrophy in early Alzheimer’s Disease (AD regions). Non-smokers (n = 41) and smokers (n = 41), 22–70 years of age, completed a 4T MRI study. Regional cortical thickness was quantitated via FreeSurfer. In smokers, associations between smoking severity, decisionmaking, impulsivity, and regional cortical thickness were examined. Smokers demonstrated cortical thinning in the medial and lateral OFC, insula, entorhinal, fusiform, middle temporal, and Composite AD regions. In Smokers, greater pack-years were associated with thinner lateral OFC, middle temporal, inferior parietal, fusiform, precuneus, and Composite AD regions. In Smokers, poorer decision-making/greater risk taking was related to thinner cortices in caudal ACC, rostral middle frontal and superior frontal gyri, and Composite ESER. Higher self-reported impulsivity was associated with thinner rostral and caudal ACC. This study provides additional evidence that cigarette smoking is associated with thinner cortices in regions implicated in the development and maintenance of substance use disorders and in regions demonstrating significant atrophy in early AD. The novel structure-function relationships in Smokers further our understanding of the neurobiological substrates potentially underlying the neuropsychological abnormalities documented in smokers.
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影响因子：
2.6
作者：
Clark, L;Manes, F;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
10.6
作者：
Dinur-Klein, Limor;Dannon, Pinhas;Zangen, Abraham
通讯作者：
Zangen, Abraham
影响因子：
4.2
作者：
Durazzo TC;Meyerhoff DJ;Nixon SJ
通讯作者：
Nixon SJ
DOI：
10.1111/j.1530-0277.2011.01452.x
发表时间：
2011-06
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Durazzo TC;Tosun D;Buckley S;Gazdzinski S;Mon A;Fryer SL;Meyerhoff DJ
通讯作者：
Meyerhoff DJ
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI