Interactive effects of chronic cigarette smoking and age on hippocampal volumes.
Interactive effects of chronic cigarette smoking and age on hippocampal volumes.
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DOI：
10.1016/j.drugalcdep.2013.08.020
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发表时间：
2013-12-01
影响因子：
4.2
通讯作者：
Nixon SJ
中科院分区：
文献类型：
--
作者：
Durazzo TC;Meyerhoff DJ;Nixon SJ
以前的横断面MRI研究与健康，10-中年成人报告吸烟者和非吸烟者之间的总海马体积没有显着差异。然而，这些研究并没有专门测试吸烟者的总海马或海马子区域中与年龄相关的更大体积损失，并且他们没有检查海马和子区域体积与情景学习和记忆表现之间的关系。比较了健康的中年至中年（45 ± 12岁）吸烟者（n = 39）和非吸烟者（n = 43）的高分辨率4特斯拉MRI得出的总海马和子区域体积，强调测试吸烟者中与年龄相关的更大体积损失。海马体积和情节学习和记忆的措施之间的关联进行了检查。吸烟者显示出显着较小的体积，以及更大的容量损失随着年龄的增长比非吸烟者在双边总海马和多个子字段。在吸烟者中，更大的包年与总海马，前下托和下托的体积较小。在整个队列中，学习和记忆指标的表现与较大的总海马和几个子区域体积有关，主要是在左半球。在这个10岁至中年队列中，慢性吸烟与较小的总海马和子区域体积相关，随着年龄的增长而加剧。研究结果还表明，不良的吸烟剂量/持续时间反应（即，包-年）与总海马和选择子区域体积。吸烟者海马体积的异常可能与以往研究报道的中年至中年吸烟者的情景学习和记忆缺陷有关。
Previous cross-sectional MRI studies with healthy, young-to-middle-aged adults reported no significant differences between smokers and non-smokers on total hippocampal volume. However, these studies did not specifically test for greater age-related volume loss in the total hippocampus or hippocampal subregions in smokers, and did they did not examine relationships between hippocampal and subfield volumes and episodic learning and memory performance. Healthy, young-to-middle-aged (45 ± 12 years of age) smokers (n = 39) and non-smokers (n = 43) were compared on total hippocampal and subfield volumes derived from high-resolution 4 Tesla MRI, emphasizing testing for greater age-related volume losses in smokers. Associations between hippocampal volumes and measures of episodic learning and memory were examined. Smokers showed significantly smaller volumes, as well as greater volume loss with increasing age than non-smokers in the bilateral total hippocampus and multiple subfields. In smokers, greater pack-years were associated with smaller volumes of the total hippocampus, presubiculum, and subiculum. In the entire cohort, performance on measures of learning and memory was related to larger total hippocampal and several subfield volumes, predominately in the left hemisphere. Chronic cigarette smoking in this young-to-middle aged cohort was associated with smaller total hippocampal and subfield volumes, which were was exacerbated by advancing age. Findings also indicated an adverse smoking dose/duration response (i.e., pack-years) with total hippocampal and select subfield volumes. These hippocampal volume abnormalities in smokers may be related to the deficiencies in episodic learning and memory in young-to-middle-aged smokers reported in previous studies.
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影响因子：
9.9
作者：
Chalela, JA;Wolf, RL;Kasner, SE
通讯作者：
Kasner, SE
影响因子：
3.6
作者：
Anbarasi, K;Vani, G;Devi, CSS
通讯作者：
Devi, CSS
影响因子：
2.1
作者：
Apostolova LG;Green AE;Babakchanian S;Hwang KS;Chou YY;Toga AW;Thompson PM
通讯作者：
Thompson PM
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI