Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers.
Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers.
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年轻成人低频率吸烟者对尼古丁含量降低香烟的反应。
DOI：
10.1007/s00213-021-05864-1
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发表时间：
2021-09
影响因子：
3.4
通讯作者：
McClernon FJ
中科院分区：
文献类型：
--
作者：
Sweitzer MM;Pacek LR;Kozink RV;Locey E;Kollins SH;Donny EC;McClernon FJ
将香烟中的尼古丁含量降低至≤ 2.4 mg/g烟草[mg/g]，可减少成年每日吸烟者的吸烟行为和毒物暴露。然而，尼古丁含量相似的香烟可以支持不经常吸烟的年轻人继续进行实验和吸烟进展。这项研究评估了香烟中尼古丁的阈值，该阈值产生与不经常吸烟的年轻人样本中吸烟进展相关的反应。年轻人（n=87，18-25岁，49%女性）每月使用烟草制品≤15天，完成了三次平衡、双盲治疗，每次测量对含有三种不同尼古丁含量之一的试验用香烟的固定剂量烟雾的阳性和阴性主观反应：正常（NNC; 15.8 mg/g）;极低（VLNC; 0.4 mg/g）;和中等（INC; 2.4 mg/g）。在最后一次会议上，参与者选择其中一支香烟进行自我管理。VLNC组吸烟后呼吸一氧化碳高于NNC组（p<0.001）。NNC的阳性反应高于INC（p<.001），INC的阳性反应高于VLNC（p=.001）。NNC的阴性反应大于INC和VLNC（均p<0.001）; INC和VLNC没有差异。香烟的选择与均匀分布没有差异（43% NNC，25% INC，32% VLNC），但NNC或INC的选择分别与NNC和INC固定剂量治疗期间的阳性反应与阴性反应比率较高相关（p<.001）。降低尼古丁含量可能会降低大多数年轻、低频率吸烟者滥用香烟的可能性。还需要进一步的工作来确定补偿性吸烟是否会导致毒物暴露增加，以及选择尼古丁含量较低的香烟的一部分人是否会继续吸烟，而不管尼古丁含量如何。
Reducing nicotine content in cigarettes to ≤ 2.4 mg per g of tobacco [mg/g] reduces smoking behavior and toxicant exposure among adult daily smokers. However, cigarettes with similar nicotine content could support continued experimentation and smoking progression among young adults who smoke infrequently. This study evaluated the threshold for nicotine in cigarettes that produces reactions associated with smoking progression in a sample of young adults who smoke infrequently. Young adults (n=87, 18-25 years, 49% female) using tobacco products ≤15 days per month completed three counterbalanced, double-blinded sessions, each measuring Positive and Negative subjective reactions to fixed doses of smoke from investigational cigarettes containing one of three different nicotine contents: normal (NNC; 15.8 mg/g); very low (VLNC; 0.4 mg/g); and intermediate (INC; 2.4 mg/g). In a final session, participants chose one of the cigarettes to self-administer. Post-cigarette breath carbon monoxide was greater for VLNC than for NNC (p<.001). Positive reactions were greater for NNC than INC (p<.001), and for INC than VLNC (p=.001). Negative reactions were greater for NNC than INC and VLNC (both p<.001); INC and VLNC did not differ. Cigarette choices did not differ from an even distribution (43% NNC, 25% INC, 32% VLNC), but choice for NNC or INC was associated with higher ratio of Positive to Negative reactions during the NNC and INC fixed-dose sessions, respectively (p<.001). Reducing nicotine content will likely lower the abuse liability of cigarettes for most young, low-frequency smokers. Additional work is needed to determine if compensatory smoking may lead to increased toxicant exposure, and if a subset of individuals choosing lower nicotine cigarettes may continue to smoke regardless of nicotine content.
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影响因子：
3.4
作者：
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通讯作者：
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