Antibiotics at birth and later antibiotic courses: effects on gut microbiota.
Antibiotics at birth and later antibiotic courses: effects on gut microbiota.
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DOI：
10.1038/s41390-021-01494-7
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发表时间：
2022-01
影响因子：
3.6
通讯作者：
Tapiainen T
中科院分区：
文献类型：
--
作者：
Ainonen S;Tejesvi MV;Mahmud MR;Paalanne N;Pokka T;Li W;Nelson KE;Salo J;Renko M;Vänni P;Pirttilä AM;Tapiainen T
产时抗生素预防（IAP）被广泛使用，但对肠道微生物群和儿童后续健康的长期影响的证据有限。在这里，我们比较了围产期抗生素暴露和后期抗生素疗程对肠道微生物群的影响。这是一项前瞻性对照队列研究，在100名阴道分娩的婴儿中进行，这些婴儿具有不同的围产期抗生素暴露：对照（27），IAP（27），产后抗生素（24），IAP和产后抗生素（22）。在1岁时，我们对粪便样本的细菌16S核糖体RNA基因进行了下一代测序。暴露于围产期抗生素对肠道微生物群有明显的影响。拟杆菌门的丰度在对照组中显著较高，而大肠杆菌的相对丰度在对照组中显著较低。围产期抗生素对肠道菌群组成的影响大于后期抗生素的暴露（28%的参与者）。围产期抗生素暴露对1岁时的肠道微生物群有显著影响。抗生素暴露的时间似乎是在肠道微生物群中观察到的变化的关键因素。婴儿通常暴露于IAP和出生后抗生素，然后在生命的第一年接受抗生素治疗。围产期抗生素与生命最初几个月内肠道微生物群的改变有关，而关于长期影响的证据则更为有限。围产期抗生素暴露对婴儿1岁时的肠道微生物群有显著影响。围产期抗生素对肠道菌群组成的影响大于1岁时抗生素的后期疗程。
Intrapartum antibiotic prophylaxis (IAP) is widely used, but the evidence of the long-term effects on the gut microbiota and subsequent health of children is limited. Here, we compared the impacts of perinatal antibiotic exposure and later courses of antibiotic courses on gut microbiota. This was a prospective, controlled cohort study among 100 vaginally delivered infants with different perinatal antibiotic exposures: control (27), IAP (27), postnatal antibiotics (24), and IAP and postnatal antibiotics (22). At 1 year of age, we performed next-generation sequencing of the bacterial 16S ribosomal RNA gene of fecal samples. Exposure to the perinatal antibiotics had a clear impact on the gut microbiota. The abundance of the Bacteroidetes phylum was significantly higher in the control group, whereas the relative abundance of Escherichia coli was significantly lower in the control group. The impact of the perinatal antibiotics on the gut microbiota composition was greater than exposure to later courses of antibiotics (28% of participants). Perinatal antibiotic exposure had a marked impact on the gut microbiota at the age of 1 year. The timing of the antibiotic exposure appears to be the critical factor for the changes observed in the gut microbiota. Infants are commonly exposed to IAP and postnatal antibiotics, and later to courses of antibiotics during the first year of life. Perinatal antibiotics have been associated with an altered gut microbiota during the first months of life, whereas the evidence regarding the long-term impact is more limited. Perinatal antibiotic exposure had a marked impact on the infant’s gut microbiota at 1 year of age. Impact of the perinatal antibiotics on the gut microbiota composition was greater than that of the later courses of antibiotics at the age of 1 year.
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DOI：
10.1007/s10096-018-3322-7
发表时间：
2018-10-01
影响因子：
4.5
作者：
Paalanne, Niko;Husso, Aleksi;Tapiainen, Terhi
通讯作者：
Tapiainen, Terhi
DOI：
10.1111/1471-0528.15799
发表时间：
2020-01-01
影响因子：
5.8
作者：
Coker, M. O.;Hoen, A. G.;Madan, J. C.
通讯作者：
Madan, J. C.
DOI：
10.1097/mpg.0000000000000928
发表时间：
2016-02-01
影响因子：
2.9
作者：
Corvaglia, Luigi;Tonti, Giacomo;Faldella, Giacomo
通讯作者：
Faldella, Giacomo
影响因子：
9.2
作者：
McDonald D;Clemente JC;Kuczynski J;Rideout JR;Stombaugh J;Wendel D;Wilke A;Huse S;Hufnagle J;Meyer F;Knight R;Caporaso JG
通讯作者：
Caporaso JG
DOI：
10.1080/14767058.2019.1571575
发表时间：
2020-10-01
影响因子：
1.8
作者：
Metz, Torri D.;McKinney, Jennifer;Heyborne, Kent D.
通讯作者：
Heyborne, Kent D.