Binding of bacillus Calmette-Guérin-activated macrophages to tumor targets. Selective inhibition by membrane preparations from homologous and heterologous neoplastic cells.
Binding of bacillus Calmette-Guérin-activated macrophages to tumor targets. Selective inhibition by membrane preparations from homologous and heterologous neoplastic cells.
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DOI：
10.1084/jem.154.1.77
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发表时间：
1981-07-01
期刊：
影响因子：
--
通讯作者：
Adams DO
中科院分区：
文献类型：
--
作者：
Marino PA;Whisnant CC;Adams DO
活化的巨噬细胞与肿瘤细胞的结合是这些靶细胞溶解中的初始和必要事件。这里的数据表明，来自RL σ 1白血病靶标、EL-4淋巴瘤靶标和P815肥大细胞瘤靶标的膜制剂各自以剂量依赖性方式抑制其同源靶标与卡介苗（BCG）活化的鼠巨噬细胞的结合。类似数量的淋巴细胞膜并没有改变三种肿瘤靶点与BCG-巨噬细胞的结合。三种靶标的膜也抑制异源肿瘤靶标的结合。P815、EL-4和RL sigma 1靶点的膜制剂的抑制活性可通过将限制浓度的膜制剂与BCG活化的巨噬细胞孵育而吸附，但不与巯基乙酸盐肉汤引发的巨噬细胞孵育。BCG巨噬细胞暴露于来自RL sigma 1、FL-4或P815靶标的膜制剂抑制了随后的三种靶标的细胞溶解。在富含质膜的制剂中，抑制活性增加。这些数据表明，三个鼠，非粘附性肿瘤的目标BCG激活的鼠巨噬细胞的结合介导的，在一定程度上，通过识别结构内存在的质膜的三个目标。
The binding of tumor cells by activated macrophages is an initial and necessary event in the cytolysis of these targets. The data here indicate that membrane preparations from RL sigma 1 leukemia targets, EL-4 lymphoma targets, and P815 mastocytoma targets each inhibited binding of its homologous target to bacillus Calmette-Guerin (BCG)- activated murine macrophages in a dose-dependent fashion. Similar amounts of membrane from lymphocytes did not alter binding of the three neoplastic target to BCG-macrophages. Membranes of the three targets also inhibited binding of the heterologous neoplastic targets. Inhibitory activity of membrane preparations from P815, EL-4, and RL sigma 1 targets could be adsorbed by incubation of limiting concentrations of the membrane preparations with BCG-activated macrophages but not with thioglycollate broth-elicited macrophages. Exposure of BCG macrophages to membrane preparations from RL sigma 1, FL-4, or P815 targets inhibited subsequent cytolysis of the three targets. Inhibitory activity was increased in preparations enriched for plasma membrane. The data suggest that binding of three murine, nonadherent neoplastic targets to BCG-activated murine macrophages is mediated, in part, by recognition structures present within the plasma membranes of the three targets.
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影响因子：
4.3
作者：
MELTZER, MS;TUCKER, RW;BREUER, AC
通讯作者：
BREUER, AC
DOI：
10.1093/jnci/54.5.1177
发表时间：
1975-01-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
MELTZER, MS;TUCKER, RW;LEONARD, EJ
通讯作者：
LEONARD, EJ
DOI：
10.1016/0304-419x(76)90004-4
发表时间：
1976-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
CURRIE, G
通讯作者：
CURRIE, G
影响因子：
4.3
作者：
FIDLER, IJ;ROBLIN, RO;POSTE, G
通讯作者：
POSTE, G
DOI：
10.1098/rspb.1978.0034
发表时间：
1978-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BRAMWELL, ME;HARRIS, H
通讯作者：
HARRIS, H