What do we know about the role of lncRNAs in multiple sclerosis?
What do we know about the role of lncRNAs in multiple sclerosis?
复制标题
我们对lncRNA在多发性硬化中的作用了解多少？
DOI：
10.4103/1673-5374.306061
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发表时间：
2021-09
影响因子：
6.1
通讯作者：
Santoro M
中科院分区：
文献类型：
--
作者：
Nociti V;Santoro M
多发性硬化症是一种病因不明的中枢神经系统慢性炎症性退行性疾病，尽管明确的证据支持自身免疫发病机制。到目前为止，导致自身免疫性疾病的确切机制仍然只是部分了解。我们知道，遗传，表观遗传，分子和细胞因素导致致病性炎症反应肯定参与。长链非编码RNA（longnon-codingRNA，lncRNA）是一类长度超过200个核苷酸的非蛋白质编码转录物，在先天性免疫和获得性免疫中起着重要作用，因此对自身免疫性疾病中的lncRNA的研究引起了人们极大的兴趣。关于lncRNA在多发性硬化症发病机制中的分子作用及其作为诊断和预后生物标志物的潜在应用的许多研究丰富了对多发性硬化症的研究。特别地，许多多发性硬化症研究领域基于lncRNA作为可能的生物标志物的鉴定，所述生物标志物能够预测疾病的发作、其活动程度、其进展阶段和对疾病修饰药物的反应。最后但并非最不重要的是，对lncRNA的研究可以为新疗法提供新的分子靶点，到目前为止，还没有治愈多发性硬化症。虽然我们对lncRNA在多发性硬化症中的作用的认识最近有所提高，但需要进一步的研究来更好地了解lncRNA在这种神经系统疾病中的具体作用。在这篇综述中，我们提出了最新的研究lncRNA的分子特征在多发性硬化症讨论其作为诊断和治疗的生物标志物的临床意义。
Multiple sclerosis is a chronic, inflammatory and degenerative disease of the central nervous system of unknown aetiology although well-defined evidence supports an autoimmune pathogenesis. So far, the exact mechanisms leading to autoimmune diseases are still only partially understood. We know that genetic, epigenetic, molecular, and cellular factors resulting in pathogenic inflammatory responses are certainly involved. Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides that play an important role in both innate and acquired immunity, so there is great interest in lncRNAs involved in autoimmune diseases. The research on multiple sclerosis has been enriched with many studies on the molecular role of lncRNAs in the pathogenesis of the disease and their potential application as diagnostic and prognostic biomarkers. In particular, many multiple sclerosis fields of research are based on the identification of lncRNAs as possible biomarkers able to predict the onset of the disease, its activity degree, its progression phase and the response to disease-modifying drugs. Last but not least, studies on lncRNAs can provide a new molecular target for new therapies, missing, so far, a cure for multiple sclerosis. While our knowledge on the role of lncRNA in multiple sclerosis has recently improved, further studies are required to better understand the specific role of lncRNAs in this neurological disease. In this review, we present the most recent studies on molecular characterization of lncRNAs in multiple sclerosis disorder discussing their clinical relevance as biomarkers for diagnosis and treatments.
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影响因子：
10.5
作者：
Cabili, Moran N.;Trapnell, Cole;Rinn, John L.
通讯作者：
Rinn, John L.
影响因子：
3.1
作者：
Bahrami, Tayyeb;Taheri, Mohammad;Karimipoor, Morteza
通讯作者：
Karimipoor, Morteza
影响因子：
4
作者：
Dastmalchi, Romina;Ghafouri-Fard, Soudeh;Taheri, Mohammad
通讯作者：
Taheri, Mohammad
影响因子：
29.7
作者：
Atianand MK;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
DOI：
10.1016/j.jaci.2016.06.014
发表时间：
2017-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Austin PJ;Tsitsiou E;Boardman C;Jones SW;Lindsay MA;Adcock IM;Chung KF;Perry MM
通讯作者：
Perry MM