Shaky scaffolding: Age differences in cerebellar activation revealed through activation likelihood estimation meta-analysis.
Shaky scaffolding: Age differences in cerebellar activation revealed through activation likelihood estimation meta-analysis.
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DOI：
10.1002/hbm.25191
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发表时间：
2020-12-15
影响因子：
4.8
通讯作者：
Goen JRM
中科院分区：
文献类型：
--
作者：
Bernard JA;Nguyen AD;Hausman HK;Maldonado T;Ballard HK;Jackson TB;Eakin SM;Lokshina Y;Goen JRM
认知神经科学研究为衰老提供了基础性的见解，但主要集中在大脑皮层。然而，小脑受到衰老的影响。鉴于小脑结构在运动和认知任务中的重要性，小脑的差异为行为的年龄差异提供了重要的见解。然而，我们对衰老过程中小脑功能激活的理解是有限的。因此，我们完成了跨任务领域的神经影像学研究的Meta分析。与大脑皮层不同，在认知任务执行过程中，随着年龄的增长，双侧激活增加，相对于年轻人，老年人（OAs）的小脑激活在任务中的重叠较少。相反，我们看到在运动任务中，OAs的激活重叠增加。我们建议，这是由于输入比较器处理的控制理论（皮质和脊髓）的背景下，可能会受到不同的影响，在老化。这些发现促进了我们对大脑和大脑衰老的理解。使用激活似然估计Meta分析，这项工作研究了年轻人和老年人小脑激活模式的年龄差异。与在任务领域中看到更多双边激活的皮层不同，在小脑中，我们发现与年轻人相比，老年人的认知任务收敛较少，但老年人的运动任务收敛更广泛。我们认为这是由于在控制理论（皮层和脊髓）的背景下，比较器处理的输入可能会在老化过程中受到不同的影响
Cognitive neuroscience research has provided foundational insights into aging, but has focused primarily on the cerebral cortex. However, the cerebellum is subject to the effects of aging. Given the importance of this structure in the performance of motor and cognitive tasks, cerebellar differences stand to provide critical insights into age differences in behavior. However, our understanding of cerebellar functional activation in aging is limited. Thus, we completed a meta‐analysis of neuroimaging studies across task domains. Unlike in the cortex where an increase in bilateral activation is seen during cognitive task performance with advanced age, there is less overlap in cerebellar activation across tasks in older adults (OAs) relative to young. Conversely, we see an increase in activation overlap in OAs during motor tasks. We propose that this is due to inputs for comparator processing in the context of control theory (cortical and spinal) that may be differentially impacted in aging. These findings advance our understanding of the aging mind and brain. Using activation likelihood estimation meta‐analysis, this work investigated age differences in cerebellar activation patterns in young and older adults. Unlike in the cortex where more bilateral activation is seen across task domains, in the cerebellum we found less convergence across cognitive tasks in older adults compared to young, but for motor tasks convergence in older adults was more extensive. We propose that this is due to inputs for comparator processing in the context of control theory (cortical and spinal) that may be differentially impacted in aging
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